6cq1: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6cq1 is ~~ON HOLD~~ ~~until Paper Publication~~

==BCL6 BTB domain in complex with 15a==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6cq1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CQ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CQ1 FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F8J:2-{6-({[2-(1H-indol-3-yl)ethyl]carbamothioyl}amino)-3-[(4-methylpiperazin-1-yl)methyl]-1H-indol-1-yl}-N-(propan-2-yl)acetamide'>F8J</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cq1 OCA], [http://pdbe.org/6cq1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cq1 RCSB], [http://www.ebi.ac.uk/pdbsum/6cq1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cq1 ProSAT]</span></td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.

== Function ==

[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Cheng, H]]

[[Category: Cierpicki, T]]

[[Category: Linhares, B M]]

[[Category: Xue, F]]

[[Category: Protein binding]]

[[Category: Protein binding-inhibitor complex]]

[[Category: Protein protein inhibitor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6cq1 is ON HOLD  until Paper Publication
+==BCL6 BTB domain in complex with 15a==
+<StructureSection load='6cq1' size='340' side='right'caption='[[6cq1]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6cq1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CQ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CQ1 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F8J:2-{6-({[2-(1H-indol-3-yl)ethyl]carbamothioyl}amino)-3-[(4-methylpiperazin-1-yl)methyl]-1H-indol-1-yl}-N-(propan-2-yl)acetamide'>F8J</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cq1 OCA], [http://pdbe.org/6cq1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cq1 RCSB], [http://www.ebi.ac.uk/pdbsum/6cq1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cq1 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions.  Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.  Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
+== Function ==
+[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Cheng, H]]
+[[Category: Cierpicki, T]]
+[[Category: Linhares, B M]]
+[[Category: Xue, F]]
+[[Category: Protein binding]]
+[[Category: Protein binding-inhibitor complex]]
+[[Category: Protein protein inhibitor]]