6d08: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6d08 is ~~ON HOLD until Apr 10 2020~~

==Crystal structure of an engineered bump-hole complex of mutant human chromobox homolog 1 (CBX1) with H3K9bn peptide==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6d08]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D08 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D08 FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=FQA:'>FQA</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d08 OCA], [http://pdbe.org/6d08 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d08 RCSB], [http://www.ebi.ac.uk/pdbsum/6d08 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d08 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/CBX1_HUMAN CBX1_HUMAN]] Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Arora, S]]

[[Category: Horne, W S]]

[[Category: Islam, K]]

[[Category: Bump-hole]]

[[Category: Chromodomain]]

[[Category: Epigenetic]]

[[Category: Lysine modification]]

[[Category: Protein binding]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6d08 is ON HOLD  until Apr 10 2020
+==Crystal structure of an engineered bump-hole complex of mutant human chromobox homolog 1 (CBX1) with H3K9bn peptide==
+<StructureSection load='6d08' size='340' side='right'caption='[[6d08]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6d08]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D08 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=FQA:'>FQA</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d08 OCA], [http://pdbe.org/6d08 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d08 RCSB], [http://www.ebi.ac.uk/pdbsum/6d08 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d08 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CBX1_HUMAN CBX1_HUMAN]] Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Arora, S]]
+[[Category: Horne, W S]]
+[[Category: Islam, K]]
+[[Category: Bump-hole]]
+[[Category: Chromodomain]]
+[[Category: Epigenetic]]
+[[Category: Lysine modification]]
+[[Category: Protein binding]]