6gaj: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6gaj is ~~ON HOLD~~

==Crystal structure of the T1L reovirus sigma1 coiled coil tail (iodide)==

~~Authors~~: ~~Dietrich~~, M.H., ~~Stehle~~, S.

== Structural highlights ==

<table><tr><td colspan='2'>[[6gaj]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GAJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GAJ FirstGlance]. <br>

~~Description~~: ~~Crystal structure~~ of ~~the T1L reovirus sigma1 coiled coil tail~~ (~~iodide~~)

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gaj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gaj OCA], [http://pdbe.org/6gaj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gaj RCSB], [http://www.ebi.ac.uk/pdbsum/6gaj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gaj ProSAT]</span></td></tr>

[[Category: ~~Dietrich~~, ~~M.H~~]]

</table>

[[Category: ~~Stehle, S~~]]

== Function ==

[[http://www.uniprot.org/uniprot/SIGM1_REOVL SIGM1_REOVL]] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis (By similarity).

__TOC__

</StructureSection>

[[Category: Dietrich, M H]]

[[Category: Stehle, T]]

[[Category: Cell attachment protein]]

[[Category: Coiled coil]]

[[Category: Reovirus sigma1]]

[[Category: Viral protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6gaj is ON HOLD
+==Crystal structure of the T1L reovirus sigma1 coiled coil tail (iodide)==
+<StructureSection load='6gaj' size='340' side='right' caption='[[6gaj]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
-Authors: Dietrich, M.H., Stehle, S.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6gaj]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GAJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GAJ FirstGlance]. <br>
-Description: Crystal structure of the T1L reovirus sigma1 coiled coil tail (iodide)
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gaj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gaj OCA], [http://pdbe.org/6gaj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gaj RCSB], [http://www.ebi.ac.uk/pdbsum/6gaj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gaj ProSAT]</span></td></tr>
-[[Category: Dietrich, M.H]]
+</table>
-[[Category: Stehle, S]]
+== Function ==
+[[http://www.uniprot.org/uniprot/SIGM1_REOVL SIGM1_REOVL]] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Dietrich, M H]]
+[[Category: Stehle, T]]
+[[Category: Cell attachment protein]]
+[[Category: Coiled coil]]
+[[Category: Reovirus sigma1]]
+[[Category: Viral protein]]