5h8s: Difference between revisions

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==Structure of the human GluA2 LBD in complex with GNE3419==
==Structure of the human GluA2 LBD in complex with GNE3419==
<StructureSection load='5h8s' size='340' side='right' caption='[[5h8s]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='5h8s' size='340' side='right'caption='[[5h8s]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5h8s]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H8S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H8S FirstGlance]. <br>
<table><tr><td colspan='2'>[[5h8s]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H8S FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5YC:7-[[ETHYL(PHENYL)AMINO]METHYL]-2-METHYL-[1,3,4]THIADIAZOLO[3,2-A]PYRIMIDIN-5-ONE'>5YC</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.703&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5h8f|5h8f]], [[5h8h|5h8h]], [[5h8n|5h8n]], [[5h8q|5h8q]], [[5h8r|5h8r]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5YC:7-[[ETHYL(PHENYL)AMINO]METHYL]-2-METHYL-[1,3,4]THIADIAZOLO[3,2-A]PYRIMIDIN-5-ONE'>5YC</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GRIA2, GLUR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h8s OCA], [https://pdbe.org/5h8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h8s RCSB], [https://www.ebi.ac.uk/pdbsum/5h8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h8s ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h8s OCA], [http://pdbe.org/5h8s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h8s RCSB], [http://www.ebi.ac.uk/pdbsum/5h8s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h8s ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GRIA2_HUMAN GRIA2_HUMAN]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:20614889</ref>
[https://www.uniprot.org/uniprot/GRIA2_HUMAN GRIA2_HUMAN] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:20614889</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5h8s" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5h8s" style="background-color:#fffaf0;"></div>
==See Also==
*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Lupardus, P J]]
[[Category: Large Structures]]
[[Category: Wallweber, H J.A]]
[[Category: Lupardus PJ]]
[[Category: Glun1]]
[[Category: Wallweber HJA]]
[[Category: Glun2a]]
[[Category: Nmda]]
[[Category: Receptor]]
[[Category: Transport protein]]
Retrieved from "https://proteopedia.org/5h8s"