5jw6

Cystal structure of aspartate semialdehyde dehydrogenase from Aspergillus fumigatus

spinqualitylabelsall models 5jw6, resolution 2.39Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5jw6 is a 2 chain structure with sequence from Aspfu. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: SO4 Gene: AFUA_3G06830 (ASPFU) Activity: Aspartate-semialdehyde dehydrogenase, with EC number 1.2.1.11 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Aspartate-semialdehyde dehydrogenase (ASADH) functions at a critical junction in the aspartate biosynthetic pathway and represents a validated target for antimicrobial drug design. This enzyme catalyzes the NADPH-dependent reductive dephosphorylation of beta-aspartyl phosphate to produce the key intermediate aspartate semialdehyde. The absence of this entire pathway in humans and other mammals will allow the selective targeting of pathogenic microorganisms for antimicrobial development. Here, the X-ray structure of a new form of ASADH from the pathogenic fungal species Aspergillus fumigatus has been determined. The overall structure of this enzyme is similar to those of its bacterial orthologs, but there are some critical differences both in biological assembly and in secondary-structural features that can potentially be exploited for the development of species-selective drugs with selective toxicity against infectious fungal organisms. Structure of a fungal form of aspartate-semialdehyde dehydrogenase from Aspergillus fumigatus.,Dahal GP, Viola RE Acta Crystallogr F Struct Biol Commun. 2017 Jan 1;73(Pt 1):36-44. doi:, 10.1107/S2053230X16020070. Epub 2017 Jan 1. PMID:28045392 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Aspartate-semialdehyde dehydrogenase 3D structures

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