1w33: Difference between revisions
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[[Image:1w33.gif|left|200px]]<br /> | [[Image:1w33.gif|left|200px]]<br /><applet load="1w33" size="450" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1w33" size="450" color="white" frame="true" align="right" spinBox="true" | |||
caption="1w33, resolution 2.7Å" /> | caption="1w33, resolution 2.7Å" /> | ||
'''BBCRASP-1 FROM BORRELIA BURGDORFERI'''<br /> | '''BBCRASP-1 FROM BORRELIA BURGDORFERI'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1W33 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi] with GOL as [http://en.wikipedia.org/wiki/ligand ligand]. | 1W33 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi] with GOL as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Gol Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W33 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: tick]] | [[Category: tick]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 18:28:28 2007'' | ||
Revision as of 16:18, 18 December 2007
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BBCRASP-1 FROM BORRELIA BURGDORFERI
Overview
Borrelia burgdorferi, a spirochete transmitted to human hosts during, feeding of infected Ixodes ticks, is the causative agent of Lyme disease., Serum-resistant B. burgdorferi strains cause a chronic, multisystemic form, of the disease and bind complement factor H (FH) and FH-like protein 1, (FHL-1) on the spirochete surface. Here we report the atomic structure for, the key FHL-1- and FH-binding protein BbCRASP-1 and reveal a homodimer, that presents a novel target for drug design.
About this Structure
1W33 is a Single protein structure of sequence from Borrelia burgdorferi with GOL as ligand. Known structural/functional Site: AC1. Full crystallographic information is available from OCA.
Reference
A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi., Cordes FS, Roversi P, Kraiczy P, Simon MM, Brade V, Jahraus O, Wallis R, Skerka C, Zipfel PF, Wallich R, Lea SM, Nat Struct Mol Biol. 2005 Mar;12(3):276-7. Epub 2005 Feb 13. PMID:15711564
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