DAHP synthase: Difference between revisions

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== Function ==
== Function ==


'''DAHP synthase''' or '''3-deoxy-D-arabino-heptulosonate 7-phosphate synthase''' (DAHPS) catalyzes the conversion of phosphoenolpyruvate (PEP) and D-erythrose 4-phosphate to 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) and phosphate.  DAHPS is part of the shikimate pathway.  DAHPS requires a bivalent metal ion cofactor for normal activity. <scene name='70/708806/Cv/2'>DAHPS is a tetramer</scene>.  DAHPS exhibits feedback inhibition by aromatic amino acids like tyrosine, phenylalanine and tryptophan.<ref>PMID:1682314</ref>
'''DAHP synthase''' or '''3-deoxy-D-arabino-heptulosonate 7-phosphate synthase''' (DAHPS) catalyzes the conversion of phosphoenolpyruvate (PEP) and D-erythrose 4-phosphate to 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) and phosphate.  DAHPS is part of the shikimate pathway.  DAHPS requires a bivalent metal ion cofactor for normal activity. <scene name='70/708806/Cv/6'>DAHPS is a tetramer</scene>.  DAHPS exhibits feedback inhibition by aromatic amino acids like tyrosine, phenylalanine and tryptophan.<ref>PMID:1682314</ref>


== Structural highlights ==
== Structural highlights ==


The DAHPS active site is located in a channel at the C-terminal of the enzyme where the <scene name='70/708806/Cv/4'>substrate (PEP)</scene>, <scene name='70/708806/Cv/5'>inhibitor (phenylalanine)</scene> and <scene name='70/708806/Cv/3'>metal ion (Mn+2)</scene> are seen. The bivalent metal is bound to a Cys-X-X-His motif.<ref>PMID:12126632</ref>
The DAHPS active site is located in a channel at the C-terminal of the enzyme where the <scene name='70/708806/Cv/7'>substrate (PEP)</scene>, <scene name='70/708806/Cv/8'>inhibitor (phenylalanine)</scene> and <scene name='70/708806/Cv/9'>metal ion (Mn+2)</scene> are seen. The bivalent metal is bound to a Cys-X-X-His motif.<ref>PMID:12126632</ref>


</StructureSection>
</StructureSection>

Revision as of 10:39, 21 February 2019

E. coli DAHP synthase complex with PEP, phenylalanine, sulfate and Mn+2 ion (PDB code 1kfl)

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3D Structures of DAHP synthase

Updated on 21-February-2019

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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