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| == Structural highlights == | | == Structural highlights == |
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| <scene name='48/484818/Cv/2'>Tribromophenol and an O2 molecule are seen in the heme-containing active site</scene>. <ref>PMID:23480178</ref> | | <scene name='48/484818/Cv/3'>Tribromophenol and an O2 molecule are seen in the heme-containing active site</scene>. <ref>PMID:23480178</ref> |
| </StructureSection> | | </StructureSection> |
| ==3D structures of dehaloperoxidase== | | ==3D structures of dehaloperoxidase== |
Revision as of 10:56, 21 February 2019
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Dehaloperoxidase (DHP) is a heme-containing globin possessing peroxidase enzymatic activity. DHP catalyzes the peroxide-dependent dehalogenation of halophenol. DHP A and DHP B are isoenzymes of DHP.[1]
Structural highlights
Tribromophenol and an O2 molecule are seen in the heme-containing active site. [2]
- ↑ Barrios DA, D'Antonio J, McCombs NL, Zhao J, Franzen S, Schmidt AC, Sombers LA, Ghiladi RA. Peroxygenase and oxidase activities of dehaloperoxidase-hemoglobin from Amphitrite ornata. J Am Chem Soc. 2014 Jun 4;136(22):7914-25. doi: 10.1021/ja500293c. Epub 2014 May , 21. PMID:24791647 doi:https://dx.doi.org/10.1021/ja500293c
- ↑ Zhao J, de Serrano VS, Zhao J, Le PD, Franzen S. Structural and kinetic study of an internal substrate binding site of dehaloperoxidase-hemoglobin A from Amphitrite ornata. Biochemistry. 2013 Mar 12. PMID:23480178 doi:https://dx.doi.org/10.1021/bi301307f
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3D structures of dehaloperoxidase
Updated on 21-February-2019
{"openlevels":0}
- Dehaloperoxidase
- 1ew6 – AoDHP – Amphitrite ornate
- 2qfk, 3dr9, 3kun, 3kuo, 3lb1, 3lb2, 3lb3, 3lb4, 3mou, 3ord, 4dwt, 4dwu – AoDHP A
- 2qfn, 3k3u, 3mym, 3myn, 3o7n, 3oj1, 4hsw, 4hsx, 4jac, 5v5r – AoDHP A (mutant)
- 3ixf, 5v5j – AoDHP B
- 5v5q, 5vlx – AoDHP B (mutant)
- DHP complex with phenol
- 1ewa – AoDHP + iodophenol
- 3ok5 - AoDHP A (mutant) + bromophenol
- 4fh6, 4fh7 - AoDHP A + tribromophenol
- 4kmv, 4kmw, 4kn3 - AoDHP A (mutant) + trichlorophenol
- 4ilz - AoDHP A + tribromophenol + O2
- 5chq - AoDHP B + nitrophenol
- 5chr - AoDHP B + nitrocatechol
- 5k1l - AoDHP B + benzimidazole
- 5lk9 - AoDHP B + indazole
- 5lkv - AoDHP B + imidazole
- 5llz - AoDHP B + benzotriazole
- DHP other complexes
References
