Sandbox GGC9: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
|||
| Line 5: | Line 5: | ||
== Function == | == Function == | ||
Collagen composed three α-chains (procollagen)in which synthesize in the ER. Collagen is a strong, rope-like molecule, that can forms stretch resistant fibers. This fibrils are the most abundant protein in our bodies. There are 20 different types of collagen in our bodies each can adapt to the needs of specific tissue. Collagen are multifunctional glycoproteins that play an important role in cellular mophogenesis, cell signalling, tissue repairing, and cell migration in the human body. These protein are ubiquitously represent in tissues as part of the basement membrane (BM), in constitute a protective layer around the blood capillaries and are include in the extra cellular matrix (ECM). Which these tissues forms protective and structural such as bones, tendons, ligaments, cartilage, and skin. | Collagen composed three α-chains (procollagen)in which synthesize in the ER. Collagen is a strong, rope-like molecule, that can forms stretch resistant fibers. This fibrils are the most abundant protein in our bodies. There are 20 different types of collagen in our bodies each can adapt to the needs of specific tissue. Collagen are multifunctional glycoproteins that play an important role in cellular mophogenesis, cell signalling, tissue repairing, and cell migration in the human body. These protein are ubiquitously represent in tissues as part of the basement membrane (BM), in constitute a protective layer around the blood capillaries and are include in the extra cellular matrix (ECM). Which these tissues forms protective and structural such as bones, tendons, ligaments, cartilage, and skin. The binding site for collagen types I and III is located in the VWF-A3 domain. However, bacterial rather have a slight different binding mechanism in which involves in cell wall anchored collagen adhesin (CNA). | ||
== Disease == | == Disease == | ||
Collagen-binding proteins(CBP) such as ECM (Extracellular Matrix) can be degrade via invasive pathogenic breach the basal lamina. Degradation of ECM can leads to major loss of mechanical containment molecules that protects the tissues from further pathogens. Furthermore, the pathogen will then degrade the interstitial space and connective tissues via ECM degrading proteases and/or the surface-bound plasminogen and matrix metalloprotein from the host. The adhesion of bacterial pathogen such as ''Staphylococcus aureus'' this particular adhesion calls "Collagen Hug". | Collagen-binding proteins(CBP) such as ECM (Extracellular Matrix) can be degrade via invasive pathogenic breach the basal lamina. Degradation of ECM can leads to major loss of mechanical containment molecules that protects the tissues from further pathogens. Furthermore, the pathogen will then degrade the interstitial space and connective tissues via ECM degrading proteases and/or the surface-bound plasminogen and matrix metalloprotein from the host. The adhesion of bacterial pathogen such as ''Staphylococcus aureus'' this particular adhesion calls "Collagen Hug". | ||
