6gbr: Difference between revisions
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==Crystal Structure of the oligomerization domain of VP35 from Reston virus, mercury derivative== | |||
<StructureSection load='6gbr' size='340' side='right' caption='[[6gbr]], [[Resolution|resolution]] 3.15Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6gbr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GBR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GBR FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MBO:MERCURIBENZOIC+ACID'>MBO</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gbr OCA], [http://pdbe.org/6gbr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gbr RCSB], [http://www.ebi.ac.uk/pdbsum/6gbr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gbr ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/VP35_EBORR VP35_EBORR]] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Baumeister, W]] | |||
[[Category: Bracher, A]] | |||
[[Category: Nagy, I]] | |||
[[Category: Orsini, M]] | |||
[[Category: Weyher-Stingl, E]] | |||
[[Category: Zinzula, L]] | |||
[[Category: Coiled-coil]] | |||
[[Category: Viral protein]] | |||
Revision as of 08:13, 10 October 2018
Crystal Structure of the oligomerization domain of VP35 from Reston virus, mercury derivative
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