6gbu: Difference between revisions
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==Crystal structure of the second SH3 domain of FCHSD2 (SH3-2) in complex with the fourth SH3 domain of ITSN1 (SH3d)== | |||
<StructureSection load='6gbu' size='340' side='right' caption='[[6gbu]], [[Resolution|resolution]] 3.44Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6gbu]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GBU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GBU FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gbu OCA], [http://pdbe.org/6gbu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gbu RCSB], [http://www.ebi.ac.uk/pdbsum/6gbu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gbu ProSAT]</span></td></tr> | |||
[[ | </table> | ||
[[ | == Function == | ||
[[ | [[http://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN]] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref> | ||
[[ | == References == | ||
[[ | <references/> | ||
[[ | __TOC__ | ||
</StructureSection> | |||
[[Category: Almeida-Souza, L]] | [[Category: Almeida-Souza, L]] | ||
[[Category: Andrews, B]] | [[Category: Andrews, B]] | ||
[[Category: Colussi, A]] | |||
[[Category: Frank, R]] | [[Category: Frank, R]] | ||
[[Category: Garcia-Nafria, J]] | |||
[[Category: Gunawardana, N]] | |||
[[Category: Howard, G]] | [[Category: Howard, G]] | ||
[[Category: | [[Category: Johnson, C M]] | ||
[[Category: | [[Category: McMahon, H T]] | ||
[[Category: Vallis, Y]] | |||
[[Category: Yu, M]] | |||
[[Category: Endocytosis]] | |||
[[Category: Sh3-sh3 complex]] | |||
Revision as of 07:44, 14 June 2018
Crystal structure of the second SH3 domain of FCHSD2 (SH3-2) in complex with the fourth SH3 domain of ITSN1 (SH3d)
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