6gcm: Difference between revisions
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==Escherichia coli DPS== | |||
<StructureSection load='6gcm' size='340' side='right'caption='[[6gcm]], [[Resolution|resolution]] 2.45Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6gcm]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Escherichia_coli_(strain_k12) Escherichia coli (strain k12)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GCM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GCM FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gcm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gcm OCA], [http://pdbe.org/6gcm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gcm RCSB], [http://www.ebi.ac.uk/pdbsum/6gcm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gcm ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [[http://www.uniprot.org/uniprot/DPS_ECOLI DPS_ECOLI]] During stationary phase, binds the chromosome non-specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. Dps also protects the cell from UV and gamma irradiation, iron and copper toxicity, thermal stress and acid and base shocks. Also shows a weak catalase activity.<ref>PMID:1340475</ref> <ref>PMID:10403254</ref> <ref>PMID:15205421</ref> <ref>PMID:15534364</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: Tereshkina, K | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Chulichkov, A L]] | |||
[[Category: Kovalenko, V V]] | |||
[[Category: Krupyanskii, Y F]] | |||
[[Category: Loiko, N G]] | |||
[[Category: Popov, A N]] | |||
[[Category: Tereshkin, E V]] | |||
[[Category: Tereshkina, K B]] | |||
[[Category: Dna binding protein]] | |||
[[Category: Dna-binding protein]] | |||
