Sandbox Reserved 1455: Difference between revisions

This RAG complex protein allows the human body to have diverse immune response. Using both RAG-1 and RAG-2 together allows for recombination to occur to create cell receptors on both B and T cells. It is critical that the cell receptors are diverse in order to recognize a wide variety of pathogens and protect the body. RAG-1 and RAG-2 appear in the body as a complex. Both RAG-1 and RAG-2 are necessary for the function of the protein. RAG-1 cannot perform all of the functions by itself associated with the RAG protein; similarly, RAG-2 cannot perform all of the functions alone.  The RAG-1 protein will bind to a specific recombination signal sequence within the  V-J region of the light chain and the D-J segment along with the V-DJ segment of a heavy chain. Next, RAG-1 will bring the various segments within close proximity, looping the DNA between the segments out. RAG-2 will then cut the RSS sequence and a different protein will bind the two DNA ends <ref name= "Article1" >Akamatsu, Yoshiko, and Marjorie A. Oettinger. “Distinct Roles of RAG1 and RAG2 in Binding the V(D)J Recombination Signal Sequences.” Molecular and Cellular Biology 18.8 (1998): 4670–4678. Print.</ref>.