Ubiquitin Structure & Function: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
|||
| Line 1: | Line 1: | ||
==Your Heading Here (maybe something like 'Structure')== | |||
<StructureSection load='3rec' size='350' side='right' caption='Escherichia coli reca protein-bound DNA (PDB entry [[3rec]])' scene=''> | |||
Anything in this section will appear adjacent to the 3D structure and will be scrollable. | |||
[[Ubiquitin]] is a single 8565 M<sub>r</sub> polypeptide consisting of 76 amino acid residues. Ubiquitin is highly known for its role in ATP-dependent protein degradation<ref name="mainpaper">PMID: 3041007</ref> | [[Ubiquitin]] is a single 8565 M<sub>r</sub> polypeptide consisting of 76 amino acid residues. Ubiquitin is highly known for its role in ATP-dependent protein degradation<ref name="mainpaper">PMID: 3041007</ref> | ||
{{STRUCTURE_1ubq| PDB=1ubq | SIZE=400| SCENE= |right|CAPTION=Human ubiquitin, [[1ubq]] }} | {{STRUCTURE_1ubq| PDB=1ubq | SIZE=400| SCENE= |right|CAPTION=Human ubiquitin, [[1ubq]] }} | ||
| Line 38: | Line 45: | ||
Infectious agents can manipulate ubiquitin or deubiquitination and one such protein is Chlamydia trachomatis. Chlamydia trachomatis' protein Cdu-1 catalyzes the hydrolysis of ubiquitin chains from Mcl-1. When polyubiquitnated, Mcl-1 is destined to be degraded by the proteasome, lowering the level of Mcl-1 and subsequently leading to apoptosis. The activity of Cdu-1 counteracts this by removing the ubiquitin, thus leading to higher levels of Mcl-1 in the cell. Additional information can be found here [[User:Karsten Theis/5B5Q]] | Infectious agents can manipulate ubiquitin or deubiquitination and one such protein is Chlamydia trachomatis. Chlamydia trachomatis' protein Cdu-1 catalyzes the hydrolysis of ubiquitin chains from Mcl-1. When polyubiquitnated, Mcl-1 is destined to be degraded by the proteasome, lowering the level of Mcl-1 and subsequently leading to apoptosis. The activity of Cdu-1 counteracts this by removing the ubiquitin, thus leading to higher levels of Mcl-1 in the cell. Additional information can be found here [[User:Karsten Theis/5B5Q]] | ||
</StructureSection> | |||
==3D structures of ubiqitin== | ==3D structures of ubiqitin== | ||
