Sandbox Reserved 1455: Difference between revisions

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== Function ==

This RAG complex protein allows the human body to have diverse immune response. Using both RAG-1 and RAG-2 together allows for recombination to occur to create cell receptors on both B and T cells. It is critical that the cell receptors are diverse in order to recognize a wide variety of pathogens and protect the body. RAG-1 and RAG-2 appear in the body as a complex. Both RAG-1 and RAG-2 are necessary for the function of the protein. RAG-1 cannot perform all of the functions by itself associated with the RAG protein; similarly, RAG-2 cannot perform all of the functions alone. The RAG-1 protein will bind to a specific recombination signal sequence within the V-J region of the light chain and the D-J segment along with the V-DJ segment of a heavy chain. Next, RAG-1 will bring the various segments within close proximity, looping the DNA between the segments out. RAG-2 will then cut the RSS sequence and a different protein will bind the two DNA ends <ref name= "Article1" >Akamatsu, Yoshiko, and Marjorie A. Oettinger. “Distinct Roles of RAG1 and RAG2 in Binding the V(D)J Recombination Signal Sequences.” Molecular and Cellular Biology 18.8 (1998): 4670–4678. Print.</ref>.

This RAG complex protein allows the human body to have diverse immune response. Using both RAG-1 and RAG-2 together allows for recombination to occur to create cell receptors on both B and T cells. It is critical that the cell receptors are diverse in order to recognize a wide variety of pathogens and protect the body. RAG-1 and RAG-2 appear in the body as a complex. Both RAG-1 and RAG-2 are necessary for the function of the protein. RAG-1 cannot perform all of the functions by itself associated with the RAG protein; similarly, RAG-2 cannot perform all of the functions alone. The RAG-1 protein will bind to a specific recombination signal sequence within the V-J region of the light chain and the D-J segment along with the V-DJ segment of a heavy chain <ref name= "Article2" >Sadofsky, Moshe J. “The RAG Proteins in V(D)J Recombination: More than Just a Nuclease.” Nucleic Acids Research 29.7 (2001): 1399–1409. Print. </ref>. Next, RAG-1 will bring the various segments within close proximity, looping the DNA between the segments out. RAG-2 will then cut the RSS sequence and a different protein will bind the two DNA ends <ref name= "Article1" >Akamatsu, Yoshiko, and Marjorie A. Oettinger. “Distinct Roles of RAG1 and RAG2 in Binding the V(D)J Recombination Signal Sequences.” Molecular and Cellular Biology 18.8 (1998): 4670–4678. Print.</ref>.

Sandbox Reserved 1455: Difference between revisions

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Revision as of 19:18, 30 April 2018 view source Leah Umbarger (talk \| contribs) 22 edits No edit summary ← Older edit		Revision as of 19:19, 30 April 2018 view source Leah Umbarger (talk \| contribs) 22 edits No edit summary Newer edit →
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	== Function ==		== Function ==
	This RAG complex protein allows the human body to have diverse immune response. Using both RAG-1 and RAG-2 together allows for recombination to occur to create cell receptors on both B and T cells. It is critical that the cell receptors are diverse in order to recognize a wide variety of pathogens and protect the body. RAG-1 and RAG-2 appear in the body as a complex. Both RAG-1 and RAG-2 are necessary for the function of the protein. RAG-1 cannot perform all of the functions by itself associated with the RAG protein; similarly, RAG-2 cannot perform all of the functions alone. The RAG-1 protein will bind to a specific recombination signal sequence within the V-J region of the light chain and the D-J segment along with the V-DJ segment of a heavy chain. Next, RAG-1 will bring the various segments within close proximity, looping the DNA between the segments out. RAG-2 will then cut the RSS sequence and a different protein will bind the two DNA ends <ref name= "Article1" >Akamatsu, Yoshiko, and Marjorie A. Oettinger. “Distinct Roles of RAG1 and RAG2 in Binding the V(D)J Recombination Signal Sequences.” Molecular and Cellular Biology 18.8 (1998): 4670–4678. Print.</ref>.		This RAG complex protein allows the human body to have diverse immune response. Using both RAG-1 and RAG-2 together allows for recombination to occur to create cell receptors on both B and T cells. It is critical that the cell receptors are diverse in order to recognize a wide variety of pathogens and protect the body. RAG-1 and RAG-2 appear in the body as a complex. Both RAG-1 and RAG-2 are necessary for the function of the protein. RAG-1 cannot perform all of the functions by itself associated with the RAG protein; similarly, RAG-2 cannot perform all of the functions alone. The RAG-1 protein will bind to a specific recombination signal sequence within the V-J region of the light chain and the D-J segment along with the V-DJ segment of a heavy chain <ref name= "Article2" >Sadofsky, Moshe J. “The RAG Proteins in V(D)J Recombination: More than Just a Nuclease.” Nucleic Acids Research 29.7 (2001): 1399–1409. Print. </ref>. Next, RAG-1 will bring the various segments within close proximity, looping the DNA between the segments out. RAG-2 will then cut the RSS sequence and a different protein will bind the two DNA ends <ref name= "Article1" >Akamatsu, Yoshiko, and Marjorie A. Oettinger. “Distinct Roles of RAG1 and RAG2 in Binding the V(D)J Recombination Signal Sequences.” Molecular and Cellular Biology 18.8 (1998): 4670–4678. Print.</ref>.