Sandbox Reserved 1448: Difference between revisions
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== Structure == | == Structure == | ||
Lactate dehydrogenase is a quaternary structure found in humans. It has two main subunits, H and M (heart and muscle). The H form converts pyruvates to lactate, while the M form converts lactate to pyruvates. Based on the different reactions the two subunits preform, different combinations can be found throughout the body. <scene name='77/778328/4h/1'>4H</scene> is found in the heart, 3H1M is found in the reticuloendothelial (part of the immune system), 2H2M is found in the kidneys, and 4M is found in the muscles and liver. | Lactate dehydrogenase is a quaternary structure found in humans. It has two main subunits, H and M (heart and muscle). The H form converts pyruvates to lactate, while the M form converts lactate to pyruvates. Based on the different reactions the two subunits preform, different combinations can be found throughout the body. <scene name='77/778328/4h/1'>4H</scene> is found in the heart, <scene name='77/778328/3h1m/1'>3H1M</scene> is found in the reticuloendothelial (part of the immune system), 2H2M is found in the kidneys, and 4M is found in the muscles and liver. | ||
== Function == | == Function == | ||
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Cook, W J, et al. “Biochemical and Structural Characterization of Cryptosporidium Parvum Lactate Dehydrogenase.” International Journal of Biological Macromolecules., U.S. National Library of Medicine, Mar. 2015, www.ncbi.nlm.nih.gov/pubmed/?term=25542170. | Cook, W J, et al. “Biochemical and Structural Characterization of Cryptosporidium Parvum Lactate Dehydrogenase.” International Journal of Biological Macromolecules., U.S. National Library of Medicine, Mar. 2015, www.ncbi.nlm.nih.gov/pubmed/?term=25542170. | ||
Kavanagh, et al. “Structure of Toxoplasma Gondii LDH1: Active-Site Differences from Human Lactate Dehydrogenases and the Structural Basis for Efficient APAD+ Use.” Biochemistry, www.rcsb.org/structure/1PZE. | |||
https://www.rcsb.org/structure/4nd4 | https://www.rcsb.org/structure/4nd4 | ||
http://proteopedia.org/wiki/index.php/Help:Editing#Citing_Literature_References | http://proteopedia.org/wiki/index.php/Help:Editing#Citing_Literature_References | ||
