Recombination-activating gene: Difference between revisions
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New page: ==Recombination Activating Gene Complex== <StructureSection load='3jbw' size='340' side='right' caption='Recombination Activating Gene Complex=''> The RAG complex protein is composed of tw... |
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==Recombination Activating Gene Complex== | ==Recombination Activating Gene Complex== | ||
<StructureSection load='3jbw' size='340' side='right' caption=' | <StructureSection load='3jbw' size='340' side='right' caption='RAG1 (grey) and RAG2 (pink) complex with DNA and Zn+2 (grey) (PDB code [[3jbw]])'> | ||
The RAG complex protein is composed of two subunits, RAG-1 and RAG-2. RAG-1 and RAG-2 are critical in T and B cell maturation, promoting an adaptive immune response. | The '''RAG complex protein''' or '''V(D)J recombination-activating protein''' is composed of two subunits, RAG-1 and RAG-2. RAG-1 and RAG-2 are critical in T and B cell maturation, promoting an adaptive immune response. | ||
== Function == | == Function == | ||
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</StructureSection> | </StructureSection> | ||
== 3D Structures of V(D)J recombination-activating protein == | |||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
{{#tree:id=OrganizedByTopic|openlevels=0| | |||
*RAG1 | |||
**[[3gna]], [[3gnb]] – mRAG1 nonamer binding domain 389-456 + DNA – mouse <br /> | |||
*RAG2 | |||
**[[2jwo]] – mRAG2 PHD finger 414-487 - NMR <br /> | |||
*RAG1+RAG2 | |||
**[[4wwx]] – mRAG1 391-1008 + RAG2 <br /> | |||
**[[5ze0]], [[5zdz]], [[5ze1]], [[5ze2]] – mRAG1 391-1008 + RAG2 (mutant) + high mobility group protein 1 + DNA<br /> | |||
**[[6cik]], [[6cil]], [[6cim]] – mRAG1 391-1008 + RAG2 + high mobility group protein 1 + DNA<br /> | |||
**[[3jbw]], [[3jbx]], [[3jby]] – mRAG1 271-1031 + RAG2 + DNA – Cryo EM<br /> | |||
**[[6cg0]], [[6cij]] – mRAG1 + RAG2 (mutant) + high mobility group protein 1 + DNA – Cryo EM<br /> | |||
**[[6dbi]], [[6dbl]], [[6dbo]], [[6dbq]], [[6dbj]], [[6dbr]], [[6dbt]], [[6dbu]], [[6dbw]], [[6dbx]], [[6dbv]] – RAG1 271-1031 + RAG2 + DNA – zebrafish -Cryo EM<br /> | |||
}} | |||
== References == | == References == | ||
<references/> | <references/> | ||
