2ho6: Difference between revisions

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[[Image:2ho6.gif|left|200px]]
[[Image:2ho6.gif|left|200px]]


{{Structure
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|DOMAIN=
{{STRUCTURE_2ho6| PDB=2ho6  | SCENE= }}  
|RELATEDENTRY=[[2ho7|2HO7]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ho6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ho6 OCA], [http://www.ebi.ac.uk/pdbsum/2ho6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ho6 RCSB]</span>
}}


'''Post-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme'''
'''Post-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme'''
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==About this Structure==
==About this Structure==
2HO6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HO6 OCA].  
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HO6 OCA].  


==Reference==
==Reference==
Structural basis of glmS ribozyme activation by glucosamine-6-phosphate., Klein DJ, Ferre-D'Amare AR, Science. 2006 Sep 22;313(5794):1752-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16990543 16990543]
Structural basis of glmS ribozyme activation by glucosamine-6-phosphate., Klein DJ, Ferre-D'Amare AR, Science. 2006 Sep 22;313(5794):1752-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16990543 16990543]
[[Category: Protein complex]]
[[Category: Amare, A R.Ferre-D.]]
[[Category: Amare, A R.Ferre-D.]]
[[Category: Klein, D J.]]
[[Category: Klein, D J.]]
[[Category: helix]]
[[Category: Helix]]
[[Category: pseudoknot]]
[[Category: Pseudoknot]]
[[Category: ribozyme]]
[[Category: Ribozyme]]
[[Category: rna]]
[[Category: Rna]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:30:32 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:33:03 2008''

Revision as of 03:30, 4 May 2008

File:2ho6.gif

Template:STRUCTURE 2ho6

Post-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme


Overview

The glmS ribozyme is the only natural catalytic RNA known to require a small-molecule activator for catalysis. This catalytic RNA functions as a riboswitch, with activator-dependent RNA cleavage regulating glmS messenger RNA expression. We report crystal structures of the glmS ribozyme in precleavage states that are unliganded or bound to the competitive inhibitor glucose-6-phosphate and in the postcleavage state. All structures superimpose closely, revealing a remarkably rigid RNA that contains a preformed active and coenzyme-binding site. Unlike other riboswitches, the glmS ribozyme binds its activator in an open, solvent-accessible pocket. Our structures suggest that the amine group of the glmS ribozyme-bound coenzyme performs general acid-base and electrostatic catalysis.

About this Structure

Full crystallographic information is available from OCA.

Reference

Structural basis of glmS ribozyme activation by glucosamine-6-phosphate., Klein DJ, Ferre-D'Amare AR, Science. 2006 Sep 22;313(5794):1752-6. PMID:16990543 Page seeded by OCA on Sun May 4 06:30:32 2008

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