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==Evidence of Kinetic Cooperativity in dimeric Ketopantoate Reductase from Staphylococcus aureus==
==Evidence of Kinetic Cooperativity in dimeric Ketopantoate Reductase from Staphylococcus aureus==
<StructureSection load='4yca' size='340' side='right' caption='[[4yca]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
<StructureSection load='4yca' size='340' side='right'caption='[[4yca]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4yca]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YCA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YCA FirstGlance]. <br>
<table><tr><td colspan='2'>[[4yca]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YCA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YCA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4s3m|4s3m]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yca OCA], [https://pdbe.org/4yca PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yca RCSB], [https://www.ebi.ac.uk/pdbsum/4yca PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yca ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CH52_06005, DA92_02185 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-dehydropantoate_2-reductase 2-dehydropantoate 2-reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.169 1.1.1.169] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yca OCA], [http://pdbe.org/4yca PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yca RCSB], [http://www.ebi.ac.uk/pdbsum/4yca PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yca ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/W8TQG0_STAAU W8TQG0_STAAU]] Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.[RuleBase:RU003776]  
[https://www.uniprot.org/uniprot/A0A0J9X283_STAAU A0A0J9X283_STAAU] Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.[RuleBase:RU362068]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 2-dehydropantoate 2-reductase]]
[[Category: Large Structures]]
[[Category: Goetze, R]]
[[Category: Staphylococcus aureus]]
[[Category: Gross, P G]]
[[Category: Goetze R]]
[[Category: Peeples, W B]]
[[Category: Gross PG]]
[[Category: Sanchez, J E]]
[[Category: Peeples WB]]
[[Category: Walsh, R M]]
[[Category: Sanchez JE]]
[[Category: Wood, Z A]]
[[Category: Walsh Jr RM]]
[[Category: Dimer]]
[[Category: Wood ZA]]
[[Category: Kinetic cooperativity]]
[[Category: Oxidoreductase]]
[[Category: Reductase]]
[[Category: Rossmann]]
Retrieved from "https://proteopedia.org/4yca"