Abrin: Difference between revisions
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<scene name='77/778334/Alpha_chain/1'></scene> | <scene name='77/778334/Alpha_chain/1'></scene> | ||
==Abrin== | ==Abrin== | ||
<StructureSection load='1ABR' size='340' side='right' caption=' | <StructureSection load='1ABR' size='340' side='right' caption='Glycosylated abrin (PDB code [[1abr]])' scene=''> | ||
== Introduction == | == Introduction == | ||
Abrus precatorius (or rosary peas) contain the protein abrin. Rosary peas are red and oval-shaped with a black edge towards one end. In some cultures, they are used to make beaded jewelry. Abrin can exhibit beneficial uses for medical research, but it can also be destructive if it directly enters an organism’s body because of its toxic properties. | ''Abrus precatorius'' (or rosary peas) contain the protein '''abrin'''. Rosary peas are red and oval-shaped with a black edge towards one end. In some cultures, they are used to make beaded jewelry. Abrin can exhibit beneficial uses for medical research, but it can also be destructive if it directly enters an organism’s body because of its toxic properties. | ||
== Structure == | == Structure == | ||
Abrin is referred to as a type-2 ribosome-inactivating protein (RIP). The protein contains two chains:<scene name='77/778334/A_chain/1'> α</scene> and <scene name='77/778334/Abrin_b_chain/1'>β</scene> which are connected by a disulfide bond. Both of the chains are <scene name='77/778334/Water/1'>water soluble</scene>. The water molecules hydrolyze the N-C glycosidic bond. The β chain allows the α chain to enter a cell because it attaches to the carbohydrate receptors. The β is composed of the following amino acids: Ile-Val-Glu-Lys-Ser-Lys-Ile-Ser-Ser-Ser-Arg-Tyr-Glu-Pro-Thr. The α chain is known as an N-glycosidase <ref>DOI:10.1093/abbs/gmw023</ref>. Once the α chain is in a cell, the chain removes adenine bases and links to the 28S rRNA<ref>DOI: 10.1007/s13181-013-0377-9</ref>. The attachment causes the ribosome to be incompetent when trying to connect to an elongation factor leading to an inhibition of protein synthesis. | Abrin is referred to as a type-2 ribosome-inactivating protein (RIP). The protein contains two chains:<scene name='77/778334/A_chain/1'> α</scene> and <scene name='77/778334/Abrin_b_chain/1'>β</scene> which are connected by a disulfide bond. Both of the chains are <scene name='77/778334/Water/1'>water soluble</scene>. The water molecules hydrolyze the N-C glycosidic bond. The β chain allows the α chain to enter a cell because it attaches to the carbohydrate receptors. The β is composed of the following amino acids: Ile-Val-Glu-Lys-Ser-Lys-Ile-Ser-Ser-Ser-Arg-Tyr-Glu-Pro-Thr. The α chain is known as an N-glycosidase <ref>DOI:10.1093/abbs/gmw023</ref>. Once the α chain is in a cell, the chain removes adenine bases and links to the 28S rRNA<ref>DOI: 10.1007/s13181-013-0377-9</ref>. The attachment causes the ribosome to be incompetent when trying to connect to an elongation factor leading to an inhibition of protein synthesis. | ||
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</StructureSection> | </StructureSection> | ||
==3D structures of abrin== | |||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
[[1abr]], [[5z37]] – IlAbr-A – Indian licorice<br /> | |||
[[5z3i]] – IlAbr-A + adenine<br /> | |||
[[5z3j]] – IlAbr-A + nicotinamide<br /> | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||
