5zt3: Difference between revisions

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'''Unreleased structure'''


The entry 5zt3 is ON HOLD
==Crystal structure of WA352 from Oryza sativa==
<StructureSection load='5zt3' size='340' side='right' caption='[[5zt3]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5zt3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZT3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZT3 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zt3 OCA], [http://pdbe.org/5zt3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zt3 RCSB], [http://www.ebi.ac.uk/pdbsum/5zt3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zt3 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Plant cytoplasmic male sterility (CMS) is an important phenomenon and is widely utilized in hybrid crop breeding. The Wild Abortive CMS (CMS-WA), a well-known CMS type, has been successfully applied in the commercial production of hybrid rice seeds for more than 40 years. The CMS-WA causal gene WA352 encodes a novel transmenbrane protein and the interacts with the mitochondrial copper chaperone COX11, triggering reactive oxygen species production and resulting in male sterility in CMS-WA lines. However, the structure of WA352 is currently unknown, and the structural mechanism whereby WA352 perturbs COX11 function to cause CMS remains largely unknown. Here, we report the crystal structure of the C-terminal functional domain of WA352 at 1.3A resolution. This functional domain, consisting of five alpha helices, is spindle-shaped with a length of 42A, and a diameter of 28A. Notably, the absence of any structural similarity to a known protein structure suggests that the WA352 functional domain is a novel fold. In addition, surface conservation analysis and structural modeling of the WA352-COX11 complex revealed details about the WA352-COX11 interaction. Further structural analysis suggested that the WA352-COX11 interaction blocks the copper ion transportation activity of COX11, which is essential for the assembly of cytochrome c oxidase, resulting in male sterility in CMS-WA lines. Our study paves the way toward structural determination of the WA352-COX11 complex and provides new insight into the mechanism of plant CMS.


Authors: Xiang, W., Zeyuan, G., Ping, Y.
Crystal structure of WA352 provides insight into cytoplasmic male sterility in rice.,Wang X, Guan Z, Gong Z, Yan J, Yang G, Liu YG, Yin P Biochem Biophys Res Commun. 2018 May 22. pii: S0006-291X(18)31136-7. doi:, 10.1016/j.bbrc.2018.05.079. PMID:29775612<ref>PMID:29775612</ref>


Description: Crystal structure of WA352 from Oryza sativa
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Zeyuan, G]]
<div class="pdbe-citations 5zt3" style="background-color:#fffaf0;"></div>
[[Category: Ping, Y]]
== References ==
[[Category: Xiang, W]]
<references/>
__TOC__
</StructureSection>
[[Category: Guan, Z]]
[[Category: Wang, X]]
[[Category: Yin, P]]
[[Category: Cytoplasmic male sterility protein]]
[[Category: Plant protein]]
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