6dbs: Difference between revisions
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==Fusion surface structure, function, and dynamics of gamete fusogen HAP2== | |||
<StructureSection load='6dbs' size='340' side='right' caption='[[6dbs]], [[Resolution|resolution]] 2.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6dbs]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DBS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DBS FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dbs OCA], [http://pdbe.org/6dbs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dbs RCSB], [http://www.ebi.ac.uk/pdbsum/6dbs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dbs ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/HAP2_CHLRE HAP2_CHLRE]] During fertilization, required on male (minus) gametes for their fusion with female (plus) gametes (PubMed:18367645, PubMed:20335357, PubMed:25655701, PubMed:28235200). Required for membrane fusion, but not for the initial adhesion between gametes (PubMed:18367645, PubMed:25655701, PubMed:28235200). Inserts (via its extracellular domain) into lipid membranes (in vitro) (PubMed:28235200). Probably initiates the fusion of gamete cell membranes by inserting its extracellular domain into the cell membrane of a female gamete (PubMed:28235200).<ref>PMID:18367645</ref> <ref>PMID:20335357</ref> <ref>PMID:25655701</ref> <ref>PMID:28235200</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Dong, X]] | |||
[[Category: Feng, J]] | |||
[[Category: Springer, T A]] | |||
[[Category: Cell fusogen]] | |||
[[Category: Class ii fusion protein]] | |||
[[Category: Gamete fertilization]] | |||
[[Category: Hydrogen deuterium exchange]] | |||
[[Category: Structural protein]] | |||
Revision as of 19:49, 19 September 2018
Fusion surface structure, function, and dynamics of gamete fusogen HAP2
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