6gfa: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6gfa is ~~ON HOLD~~

==Structure of Nucleotide binding domain of HSP110, ATP and Mg2+ complexed==

~~Authors~~: ~~Gonzalez~~, D., ~~Gotthard~~, G.~~, Gozzi, G~~.J., ~~Seigneuric, R~~.~~, Neiers, F~~., ~~Briand, L~~.~~, Garrido, C~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[6gfa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GFA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GFA FirstGlance]. <br>

~~Description~~: ~~Structure~~ of ~~Nucleotide binding domain~~ of ~~HSP110~~, ATP and ~~Mg2+ complexed~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gfa OCA], [http://pdbe.org/6gfa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gfa RCSB], [http://www.ebi.ac.uk/pdbsum/6gfa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gfa ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/HS105_HUMAN HS105_HUMAN]] Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).[UniProtKB:Q60446][UniProtKB:Q61699]<ref>PMID:24318877</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Briand, L]]

[[Category: Garrido, C]]

[[Category: Gonzalez, D]]

[[Category: Gotthard, G]]

[[Category: ~~Gonzalez~~, D]]

[[Category: Gozzi, G J]]

[[Category: Neiers, F]]

~~[[Category: Briand, L]]~~

~~[[Category: Gozzi, G.J]]~~

[[Category: Seigneuric, R]]

[[Category: ~~Garrido, C~~]]

[[Category: Chaperone]]

[[Category: Hsp105]]

[[Category: Hsp110]]

[[Category: Hsp110de9]]

[[Category: Hsph1]]

[[Category: Nucleotide-binding domain]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6gfa is ON HOLD
+==Structure of Nucleotide binding domain of HSP110, ATP and Mg2+ complexed==
+<StructureSection load='6gfa' size='340' side='right'caption='[[6gfa]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-Authors: Gonzalez, D., Gotthard, G., Gozzi, G.J., Seigneuric, R., Neiers, F., Briand, L., Garrido, C.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6gfa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GFA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GFA FirstGlance]. <br>
-Description: Structure of Nucleotide binding domain of HSP110, ATP and Mg2+ complexed
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gfa OCA], [http://pdbe.org/6gfa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gfa RCSB], [http://www.ebi.ac.uk/pdbsum/6gfa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gfa ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/HS105_HUMAN HS105_HUMAN]] Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).[UniProtKB:Q60446][UniProtKB:Q61699]<ref>PMID:24318877</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Briand, L]]
+[[Category: Garrido, C]]
+[[Category: Gonzalez, D]]
 [[Category: Gotthard, G]]
-[[Category: Gonzalez, D]]
+[[Category: Gozzi, G J]]
 [[Category: Neiers, F]]
-[[Category: Briand, L]]
-[[Category: Gozzi, G.J]]
 [[Category: Seigneuric, R]]
-[[Category: Garrido, C]]
+[[Category: Chaperone]]
+[[Category: Hsp105]]
+[[Category: Hsp110]]
+[[Category: Hsp110de9]]
+[[Category: Hsph1]]
+[[Category: Nucleotide-binding domain]]