2i1p: Difference between revisions
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{{STRUCTURE_2i1p| PDB=2i1p | SCENE= }} | |||
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'''Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin''' | '''Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin''' | ||
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[[Category: Shi, M.]] | [[Category: Shi, M.]] | ||
[[Category: Wolf, C A.]] | [[Category: Wolf, C A.]] | ||
[[Category: | [[Category: Calcium cage]] | ||
[[Category: | [[Category: Cysteine-rich repeat]] | ||
[[Category: | [[Category: Ligand binding domain]] | ||
[[Category: | [[Category: Low density lipoprotein receptor]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:58:14 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 03:58, 4 May 2008
Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin
Overview
Megalin, an approx. 600 kDa transmembrane glycoprotein that acts as multi-ligand transporter, is a member of the low density lipoprotein receptor gene family. Several cysteine-rich repeats, each consisting of about 40 residues, are responsible for the multispecific binding of ligands. The solution structure of the twelfth cysteine-rich ligand-binding repeat with class A motif found in megalin features two short beta-strands and two helical turns, yielding the typical fold with a I-III, II-V and IV-VI disulfide bridge connectivity pattern and a calcium coordination site at the C-terminal end. The resulting differences in electrostatic surface potential compared to other ligand-binding modules of this gene family, however, may be responsible for the functional divergence.
About this Structure
2I1P is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin., Wolf CA, Dancea F, Shi M, Bade-Noskova V, Ruterjans H, Kerjaschki D, Lucke C, J Biomol NMR. 2007 Apr;37(4):321-8. Epub 2007 Jan 24. PMID:17245526 Page seeded by OCA on Sun May 4 06:58:14 2008
