Enolase: Difference between revisions
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Enolase is present in all tissues and organisms with the ability to do glycolysis or fermentation. Recent studies have Enolase concentration samples in order to determine certain conditions and their severity. For instance, high concentrations of Enolase in cerebrospinal fluid (CSF) are more strongly associated with astrocytoma than other enzymes like aldolase, pyruvate kinase, and creatine kinase. High concentrations of Enolase in the CSF are also linked to the fastest rate of tumor growth and increased chances of heart attack or stroke. | Enolase is present in all tissues and organisms with the ability to do glycolysis or fermentation. Recent studies have Enolase concentration samples in order to determine certain conditions and their severity. For instance, high concentrations of Enolase in cerebrospinal fluid (CSF) are more strongly associated with astrocytoma than other enzymes like aldolase, pyruvate kinase, and creatine kinase. High concentrations of Enolase in the CSF are also linked to the fastest rate of tumor growth and increased chances of heart attack or stroke. | ||
Enolase can be competitively inhibited by fluoride for the substrate 2-PGA. In drinking water with added fluorination, oral bacteria Enolase activity is inhibited without harmed humans. This works to prevent cavities. | Enolase can be competitively inhibited by fluoride for the substrate 2-PGA. In drinking water with added fluorination, oral bacteria Enolase activity is inhibited without harmed humans. This works to prevent cavities. | ||
</StructureSection> | |||
==3D structures of enolase== | |||
[[Enolase 3D structures]] | |||
</StructureSection> | |||
==3D structures of enolase== | ==3D structures of enolase== | ||
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**[[4z17]] - CaENO + PEP <br /> | **[[4z17]] - CaENO + PEP <br /> | ||
**[[4z1y]] - CaENO + 2PGA<br /> | **[[4z1y]] - CaENO + 2PGA<br /> | ||
**[[6j36]] - ENO – ''Mycoplasma hyopneumaniae''<br /> | |||
**[[6nb2]] – LpENO + 2PGA – ''Legionella pneumophila''<br /> | |||
**[[6nbm]] - LpENO + phosphate <br /> | |||
**[[6o4n]] - ENO + phosphate – ''Chladmydia trachomatis'' <br /> | |||
*Enolase 1 | *Enolase 1 | ||
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**[[1e9i]] - EcENO1 – ''Escherichia coli''<BR /> | **[[1e9i]] - EcENO1 – ''Escherichia coli''<BR /> | ||
**[[2xgz]], [[2xh0]], [[2xh2]], [[2xh4]], [[2xh7]] – EcENO1 residues 2-437 (mutant) <BR /> | **[[2xgz]], [[2xh0]], [[2xh2]], [[2xh4]], [[2xh7]] – EcENO1 residues 2-437 (mutant) <BR /> | ||
**[[6bfy]] - EcENO1 + 2PGA<br /> | |||
**[[6bfz]] - EcENO1 + PEP<br /> | |||
**[[3h8a]], [[2fym]], [[5ohg]] – EcENO1 + RNase E<BR /> | |||
**[[3uj2]] – ENO1 – ''Anaerostipes caccae''<br /> | **[[3uj2]] – ENO1 – ''Anaerostipes caccae''<br /> | ||
**[[3enl]], [[4enl]] – yENO1 - yeast<BR /> | **[[3enl]], [[4enl]] – yENO1 - yeast<BR /> | ||
**[[2al1]], [[2al2]], [[1ebh]] – yENO1 + Mg<BR /> | **[[2al1]], [[2al2]], [[1ebh]] – yENO1 + Mg<BR /> | ||
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**[[1ebg]], [[1els]] - yENO1 + PAH<BR /> | **[[1ebg]], [[1els]] - yENO1 + PAH<BR /> | ||
**[[1l8p]] - yENO1 (mutant) + PAH<BR /> | **[[1l8p]] - yENO1 (mutant) + PAH<BR /> | ||
**[[2one]], [[1one]] – yENO1 + PEP + | **[[2one]], [[1one]] – yENO1 + PEP + 2PGA<BR /> | ||
**[[5enl]], [[7enl]] - yENO1 + | **[[5enl]], [[7enl]] - yENO1 + 2PGA<BR /> | ||
**[[1nel]], [[6enl]] – yENO1 + inhibitor | **[[1nel]], [[6enl]] – yENO1 + inhibitor | ||
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*γ Enolase (neuron specific enolase) | *γ Enolase (neuron specific enolase) | ||
**[[1te6]], [[3ucc]], [[3ucd]], [[3uje]], [[3ujf]], [[3ujr]], [[3ujs]] – hENOγ<BR /> | **[[1te6]], [[3ucc]], [[3ucd]], [[3uje]], [[3ujf]], [[3ujr]], [[3ujs]], [[5td9]] – hENOγ<BR /> | ||
**[[2akm]], [[2akz]], [[5eu9]], [[5idz]], [[4za0]], [[4zcw]] – hENOγ + inhibitor<br /> | **[[2akm]], [[2akz]], [[5eu9]], [[5idz]], [[4za0]], [[4zcw]], [[5tij]] – hENOγ + inhibitor<br /> | ||
*2, 3-diketo-5-methylthiopentyl-1-phosphate enolase | *2, 3-diketo-5-methylthiopentyl-1-phosphate enolase | ||
