6g2k: Difference between revisions
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==Structure of HuR RRM3 in complex with RNA (UUUUUU)== | |||
<StructureSection load='6g2k' size='340' side='right' caption='[[6g2k]], [[Resolution|resolution]] 2.01Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6g2k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G2K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G2K FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[ | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g2k OCA], [http://pdbe.org/6g2k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g2k RCSB], [http://www.ebi.ac.uk/pdbsum/6g2k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g2k ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ELAV1_HUMAN ELAV1_HUMAN]] Involved in 3'-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro.<ref>PMID:19029303</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Pabis, M]] | [[Category: Pabis, M]] | ||
[[Category: Sattler, M]] | [[Category: Sattler, M]] | ||
[[Category: Rna binding protein]] | |||
Revision as of 06:56, 31 October 2018
Structure of HuR RRM3 in complex with RNA (UUUUUU)
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