5zuv: Difference between revisions
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==Crystal Structure of the Human Coronavirus 229E HR1 motif in complex with pan-CoVs inhibitor EK1== | |||
<StructureSection load='5zuv' size='340' side='right'caption='[[5zuv]], [[Resolution|resolution]] 2.21Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5zuv]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZUV FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zuv OCA], [http://pdbe.org/5zuv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zuv RCSB], [http://www.ebi.ac.uk/pdbsum/5zuv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zuv ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/SPIKE_CVH22 SPIKE_CVH22]] S1 region attaches the virion to the cell membrane by interacting with human ANPEP/aminopeptidase N, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Wilson, I A]] | |||
[[Category: Yan, L]] | |||
[[Category: Yang, B]] | |||
[[Category: Hr1 motif]] | |||
[[Category: Human coronavirus 229e]] | |||
[[Category: Inhibitor]] | |||
[[Category: Pan-coronavirus]] | |||
[[Category: S2 domain]] | |||
[[Category: Spike protein]] | |||
[[Category: Viral protein]] | |||
