6aze: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 6aze is ON HOLD until Paper Publication~~

==Crystal Structure of the BPTF PHD-bromodomain module bound to H3KC4me3 methyl lysine analog==

~~Authors: Chen, Z., Ruthenburg, A.J.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[6aze]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AZE OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AZE FirstGlance].

~~Description:~~ Crystal Structure of the BPTF PHD-bromodomain module bound to H3KC4me3 methyl lysine analog

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=ML3:2-{[(2R)-2-AMINO-2-CARBOXYETHYL]SULFANYL}-N,N,N-TRIMETHYLETHANAMINIUM'>ML3</scene></td></tr>

[[~~Category~~: ~~Ruthenburg~~, A.J]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[2f6j|2f6j]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6aze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aze OCA], [http://pdbe.org/6aze PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aze RCSB], [http://www.ebi.ac.uk/pdbsum/6aze PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aze ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN]] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.

__TOC__

</StructureSection>

[[Category: Chen, Z]]

[[Category: Ruthenburg, A J]]

[[Category: Bromodomain]]

[[Category: Gene regulation]]

[[Category: Histone reader]]

[[Category: Methyllsine analog]]

[[Category: Mla]]

[[Category: Phd-finger]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6aze is ON HOLD  until Paper Publication
+==Crystal Structure of the BPTF PHD-bromodomain module bound to H3KC4me3 methyl lysine analog==
+<StructureSection load='6aze' size='340' side='right' caption='[[6aze]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
-Authors: Chen, Z., Ruthenburg, A.J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6aze]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AZE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AZE FirstGlance]. <br>
-Description: Crystal Structure of the BPTF PHD-bromodomain module bound to H3KC4me3 methyl lysine analog
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ML3:2-{[(2R)-2-AMINO-2-CARBOXYETHYL]SULFANYL}-N,N,N-TRIMETHYLETHANAMINIUM'>ML3</scene></td></tr>
-[[Category: Ruthenburg, A.J]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2f6j|2f6j]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6aze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aze OCA], [http://pdbe.org/6aze PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aze RCSB], [http://www.ebi.ac.uk/pdbsum/6aze PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aze ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN]] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.
+__TOC__
+</StructureSection>
 [[Category: Chen, Z]]
+[[Category: Ruthenburg, A J]]
+[[Category: Bromodomain]]
+[[Category: Gene regulation]]
+[[Category: Histone reader]]
+[[Category: Methyllsine analog]]
+[[Category: Mla]]
+[[Category: Phd-finger]]