6cyo: Difference between revisions
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The entry | ==Crystal structure of human UBE2A (RAD6A)== | ||
<StructureSection load='6cyo' size='340' side='right' caption='[[6cyo]], [[Resolution|resolution]] 1.85Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6cyo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CYO FirstGlance]. <br> | |||
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/E2_ubiquitin-conjugating_enzyme E2 ubiquitin-conjugating enzyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.23 2.3.2.23] </span></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cyo OCA], [http://pdbe.org/6cyo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cyo RCSB], [http://www.ebi.ac.uk/pdbsum/6cyo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cyo ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/UBE2A_HUMAN UBE2A_HUMAN]] X-linked intellectual disability, Nascimento type. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/UBE2A_HUMAN UBE2A_HUMAN]] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.<ref>PMID:16337599</ref> <ref>PMID:20061386</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: E2 ubiquitin-conjugating enzyme]] | |||
[[Category: Oliveira, J F.de]] | |||
[[Category: Ranzani, A T]] | |||
[[Category: Ligase]] | |||
[[Category: Transferase]] | |||
[[Category: Ubiquitin-conjungating enzyme e2 some]] | |||
Revision as of 06:43, 12 December 2018
Crystal structure of human UBE2A (RAD6A)
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