2ddk: Difference between revisions

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==Crystal structure of human myo-inositol monophosphatase 2 (IMPA2) (orthorhombic form)==
==Crystal structure of human myo-inositol monophosphatase 2 (IMPA2) (orthorhombic form)==
<StructureSection load='2ddk' size='340' side='right' caption='[[2ddk]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='2ddk' size='340' side='right'caption='[[2ddk]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ddk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DDK FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ddk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DDK FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2czh|2czh]], [[2czi|2czi]], [[2czk|2czk]]</td></tr>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2czh|2czh]], [[2czi|2czi]], [[2czk|2czk]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IMPA2, IMP.18P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IMPA2, IMP.18P ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase Inositol-phosphate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase Inositol-phosphate phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ddk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ddk OCA], [http://pdbe.org/2ddk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ddk RCSB], [http://www.ebi.ac.uk/pdbsum/2ddk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ddk ProSAT], [http://www.topsan.org/Proteins/RSGI/2ddk TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ddk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ddk OCA], [https://pdbe.org/2ddk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ddk RCSB], [https://www.ebi.ac.uk/pdbsum/2ddk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ddk ProSAT], [https://www.topsan.org/Proteins/RSGI/2ddk TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/IMPA2_HUMAN IMPA2_HUMAN]] Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.<ref>PMID:17068342</ref>   
[[https://www.uniprot.org/uniprot/IMPA2_HUMAN IMPA2_HUMAN]] Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.<ref>PMID:17068342</ref>   
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Inositol Monophosphatase|Inositol Monophosphatase]]
*[[Inositol monophosphatase 3D structures|Inositol monophosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Human]]
[[Category: Human]]
[[Category: Inositol-phosphate phosphatase]]
[[Category: Inositol-phosphate phosphatase]]
[[Category: Large Structures]]
[[Category: Arai, R]]
[[Category: Arai, R]]
[[Category: Bessho, Y]]
[[Category: Bessho, Y]]
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