5zml: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5zml is ~~ON HOLD until Paper Publication~~

==Stapled-peptides tailored against initiation of translation==

~~Authors~~: ~~Lama~~, D., ~~Liberator~~, A.~~, Frosi, Y~~.~~, Nakhle, J~~.~~, Tsomia, N~~., ~~Bashir, T~~.~~, Lane, D~~.P., ~~Brown~~, C.J., ~~Verma, C~~.S., ~~Auvin, S~~.~~, Yano, J~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[5zml]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZML OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZML FirstGlance].

~~Description: Stapled-peptides tailored against initiation of translation~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene></td></tr>

~~[[Category: Brown, C.J]]~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zml OCA], [http://pdbe.org/5zml PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zml RCSB], [http://www.ebi.ac.uk/pdbsum/5zml PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zml ProSAT]</td></tr>

[[Category: ~~Tsomia~~, N]]

</table>

[[Category: ~~Nakhle~~, J]]

== Function ==

[[Category: ~~Yano~~, J]]

[[http://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN]] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Auvin, S]]

[[Category: Bashir, T]]

[[Category: Brown, C J]]

[[Category: Frosi, Y]]

~~[[Category: Verma, C.S]]~~

[[Category: Lama, D]]

[[Category: Lane, D P]]

[[Category: Liberator, A]]

[[Category: ~~Auvin~~, S]]

[[Category: Nakhle, J]]

[[Category: ~~Bashir~~, T]]

[[Category: Tsomia, N]]

[[Category: ~~Lane, D.P~~]]

[[Category: Verma, C S]]

[[Category: Yano, J]]

[[Category: Cap dependent translation]]

[[Category: Rna binding protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5zml is ON HOLD  until Paper Publication
+==Stapled-peptides tailored against initiation of translation==
+<StructureSection load='5zml' size='340' side='right' caption='[[5zml]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-Authors: Lama, D., Liberator, A., Frosi, Y., Nakhle, J., Tsomia, N., Bashir, T., Lane, D.P., Brown, C.J., Verma, C.S., Auvin, S., Yano, J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5zml]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZML FirstGlance]. <br>
-Description: Stapled-peptides tailored against initiation of translation
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene></td></tr>
-[[Category: Brown, C.J]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zml OCA], [http://pdbe.org/5zml PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zml RCSB], [http://www.ebi.ac.uk/pdbsum/5zml PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zml ProSAT]</span></td></tr>
-[[Category: Tsomia, N]]
+</table>
-[[Category: Nakhle, J]]
+== Function ==
-[[Category: Yano, J]]
+[[http://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN]] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Auvin, S]]
+[[Category: Bashir, T]]
+[[Category: Brown, C J]]
 [[Category: Frosi, Y]]
-[[Category: Verma, C.S]]
 [[Category: Lama, D]]
+[[Category: Lane, D P]]
 [[Category: Liberator, A]]
-[[Category: Auvin, S]]
+[[Category: Nakhle, J]]
-[[Category: Bashir, T]]
+[[Category: Tsomia, N]]
-[[Category: Lane, D.P]]
+[[Category: Verma, C S]]
+[[Category: Yano, J]]
+[[Category: Cap dependent translation]]
+[[Category: Rna binding protein]]