6dd3: Difference between revisions
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==Crystal structure of the double mutant (D52N/D407A) of NT5C2-537X in the active state== | |||
<StructureSection load='6dd3' size='340' side='right' caption='[[6dd3]], [[Resolution|resolution]] 1.98Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6dd3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DD3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DD3 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5'-nucleotidase 5'-nucleotidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.5 3.1.3.5] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dd3 OCA], [http://pdbe.org/6dd3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dd3 RCSB], [http://www.ebi.ac.uk/pdbsum/6dd3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dd3 ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN]] Autosomal recessive spastic paraplegia type 45. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:24482476</ref> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN]] May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides. | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: 5'-nucleotidase]] | |||
[[Category: Ambesi-Impiombato, A]] | |||
[[Category: Carpenter, Z]] | [[Category: Carpenter, Z]] | ||
[[Category: Dieck, C L]] | |||
[[Category: Ferrando, A A]] | |||
[[Category: Forouhar, F]] | [[Category: Forouhar, F]] | ||
[[Category: Kirschner-Schwabe, R]] | |||
[[Category: Lew, S]] | [[Category: Lew, S]] | ||
[[Category: Sanchez-Martin, M]] | |||
[[Category: Seetharaman, J]] | |||
[[Category: Tong, L]] | [[Category: Tong, L]] | ||
[[Category: Tzoneva, G]] | [[Category: Tzoneva, G]] | ||
[[Category: | [[Category: Hydrolase]] | ||
Revision as of 07:15, 4 July 2018
Crystal structure of the double mutant (D52N/D407A) of NT5C2-537X in the active state
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