6ddc: Difference between revisions

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'''Unreleased structure'''


The entry 6ddc is ON HOLD  until Paper Publication
==Crystal structure of the single mutant (D52N) of NT5C2-537X in the basal state, Northeast Structural Genomics Consortium Target==
 
<StructureSection load='6ddc' size='340' side='right' caption='[[6ddc]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
Authors: Forouhar, F., Dieck, C.L., Tzoneva, G., Carpenter, Z., Ambesi-Impiombato, A., Sanchez-Martin, M., Kirschner-Schwabe, R., Lew, S., Seetharaman, J., Ferrando, A.A., Tong, L., Northeast Structural Genomics Consortium (NESG)
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6ddc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DDC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DDC FirstGlance]. <br>
Description: Crystal structure of the single mutant (D52N) of NT5C2-537X in the basal state, Northeast Structural Genomics Consortium Target
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5'-nucleotidase 5'-nucleotidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.5 3.1.3.5] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ddc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ddc OCA], [http://pdbe.org/6ddc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ddc RCSB], [http://www.ebi.ac.uk/pdbsum/6ddc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ddc ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN]] Autosomal recessive spastic paraplegia type 45. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:24482476</ref> 
== Function ==
[[http://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN]] May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: 5'-nucleotidase]]
[[Category: Ambesi-Impiombato, A]]
[[Category: Carpenter, Z]]
[[Category: Carpenter, Z]]
[[Category: Dieck, C L]]
[[Category: Ferrando, A A]]
[[Category: Forouhar, F]]
[[Category: Forouhar, F]]
[[Category: Kirschner-Schwabe, R]]
[[Category: Lew, S]]
[[Category: Lew, S]]
[[Category: Northeast Structural Genomics Consortium (Nesg)]]
[[Category: Structural genomic]]
[[Category: Sanchez-Martin, M]]
[[Category: Seetharaman, J]]
[[Category: Tong, L]]
[[Category: Tong, L]]
[[Category: Kirschner-Schwabe, R]]
[[Category: Ferrando, A.A]]
[[Category: Sanchez-Martin, M]]
[[Category: Tzoneva, G]]
[[Category: Tzoneva, G]]
[[Category: Dieck, C.L]]
[[Category: Hydrolase]]
[[Category: Ambesi-Impiombato, A]]
[[Category: Nesg]]
[[Category: Seetharaman, J]]
[[Category: Psi-biology]]
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