6djp: Difference between revisions
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The | ==Integrin alpha-v beta-8 in complex with the Fabs 8B8 and 68== | ||
<StructureSection load='6djp' size='340' side='right' caption='[[6djp]], [[Resolution|resolution]] 4.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6djp]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DJP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DJP FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6djp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6djp OCA], [http://pdbe.org/6djp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6djp RCSB], [http://www.ebi.ac.uk/pdbsum/6djp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6djp ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ITAV_HUMAN ITAV_HUMAN]] The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. [[http://www.uniprot.org/uniprot/ITB8_HUMAN ITB8_HUMAN]] Integrin alpha-V/beta-8 is a receptor for fibronectin. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Campbell, M G]] | |||
[[Category: Cheng, Y]] | |||
[[Category: Cormier, A]] | |||
[[Category: Nishimura, S L]] | |||
[[Category: Adhesion]] | |||
[[Category: Fab]] | |||
[[Category: Glycoprotein]] | |||
[[Category: Membrane protein]] | |||
Revision as of 07:20, 25 July 2018
Integrin alpha-v beta-8 in complex with the Fabs 8B8 and 68
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