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==Solution structure of the SH3 domain of Abl interactor 2 (Abelson interactor 2)==
==Solution structure of the SH3 domain of Abl interactor 2 (Abelson interactor 2)==
<StructureSection load='2ed0' size='340' side='right' caption='[[2ed0]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2ed0' size='340' side='right'caption='[[2ed0]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ed0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ED0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ED0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ed0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ED0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ED0 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ABI2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ABI2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ed0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ed0 OCA], [http://pdbe.org/2ed0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ed0 RCSB], [http://www.ebi.ac.uk/pdbsum/2ed0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ed0 ProSAT], [http://www.topsan.org/Proteins/RSGI/2ed0 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ed0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ed0 OCA], [https://pdbe.org/2ed0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ed0 RCSB], [https://www.ebi.ac.uk/pdbsum/2ed0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ed0 ProSAT], [https://www.topsan.org/Proteins/RSGI/2ed0 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ABI2_HUMAN ABI2_HUMAN]] May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.<ref>PMID:7590236</ref> <ref>PMID:8649853</ref> <ref>PMID:10498863</ref>   
[[https://www.uniprot.org/uniprot/ABI2_HUMAN ABI2_HUMAN]] May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.<ref>PMID:7590236</ref> <ref>PMID:8649853</ref> <ref>PMID:10498863</ref>   
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Abe, H]]
[[Category: Abe, H]]
[[Category: Kigawa, T]]
[[Category: Kigawa, T]]
Retrieved from "https://proteopedia.org/2ed0"