2j45: Difference between revisions
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{{STRUCTURE_2j45| PDB=2j45 | SCENE= }} | |||
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'''WATER STRUCTURE OF T. AQUATICUS FFH NG DOMAIN AT 1.1A RESOLUTION''' | '''WATER STRUCTURE OF T. AQUATICUS FFH NG DOMAIN AT 1.1A RESOLUTION''' | ||
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[[Category: Freymann, D M.]] | [[Category: Freymann, D M.]] | ||
[[Category: Ramirez, U D.]] | [[Category: Ramirez, U D.]] | ||
[[Category: | [[Category: Ffh]] | ||
[[Category: | [[Category: Gtp-binding]] | ||
[[Category: | [[Category: Gtpase]] | ||
[[Category: | [[Category: Nucleotide binding]] | ||
[[Category: | [[Category: Nucleotide-binding]] | ||
[[Category: | [[Category: Ribonucleoprotein]] | ||
[[Category: | [[Category: Rna-binding]] | ||
[[Category: | [[Category: Signal recognition particle]] | ||
[[Category: | [[Category: Srp]] | ||
[[Category: | [[Category: Water]] | ||
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Revision as of 05:18, 4 May 2008
WATER STRUCTURE OF T. AQUATICUS FFH NG DOMAIN AT 1.1A RESOLUTION
Overview
Two new structures of the SRP GTPase Ffh have been determined at 1.1 A resolution and provide the basis for comparative examination of the extensive water structure of the apo conformation of these GTPases. A set of well defined water-binding positions have been identified in the active site of the two-domain ;NG' GTPase, as well as at two functionally important interfaces. The water hydrogen-bonding network accommodates alternate conformations of the protein side chains by undergoing local rearrangements and, in one case, illustrates binding of a solute molecule within the active site by displacement of water molecules without further disruption of the water-interaction network. A subset of the water positions are well defined in several lower resolution structures, including those of different nucleotide-binding states; these appear to function in maintaining the protein structure. Consistent arrangements of surface water between three different ultrahigh-resolution structures provide a framework for beginning to understand how local water structure contributes to protein-ligand and protein-protein binding in the SRP GTPases.
About this Structure
2J45 is a Single protein structure of sequence from Thermus aquaticus. Full crystallographic information is available from OCA.
Reference
Analysis of protein hydration in ultrahigh-resolution structures of the SRP GTPase Ffh., Ramirez UD, Freymann DM, Acta Crystallogr D Biol Crystallogr. 2006 Dec;62(Pt 12):1520-34. Epub 2006, Nov 23. PMID:17139088 Page seeded by OCA on Sun May 4 08:18:21 2008
