2j4a: Difference between revisions

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[[Image:2j4a.jpg|left|200px]]
[[Image:2j4a.jpg|left|200px]]


{{Structure
<!--
|PDB= 2j4a |SIZE=350|CAPTION= <scene name='initialview01'>2j4a</scene>, resolution 2.2&Aring;
The line below this paragraph, containing "STRUCTURE_2j4a", creates the "Structure Box" on the page.
|SITE= <scene name='pdbsite=AC1:Oef+Binding+Site+For+Chain+A'>AC1</scene>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
|LIGAND= <scene name='pdbligand=OEF:3,5-DIBROMO-4-(3-ISOPROPYL-PHENOXY)BENZOIC+ACID'>OEF</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY=  
or leave the SCENE parameter empty for the default display.
|GENE=  
-->
|DOMAIN=
{{STRUCTURE_2j4a| PDB=2j4a  | SCENE= }}  
|RELATEDENTRY=[[1bsx|1BSX]], [[1n46|1N46]], [[1nax|1NAX]], [[1nq0|1NQ0]], [[1nq1|1NQ1]], [[1nq2|1NQ2]], [[1nuo|1NUO]], [[1q4x|1Q4X]], [[1r6g|1R6G]], [[1xzx|1XZX]], [[1y0x|1Y0X]], [[2h6w|2H6W]], [[2nll|2NLL]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j4a OCA], [http://www.ebi.ac.uk/pdbsum/2j4a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2j4a RCSB]</span>
}}


'''HUMAN THYROID HORMONE RECEPTOR BETA LIGAND BINDING DOMAIN IN COMPLEX WITH KB131084'''
'''HUMAN THYROID HORMONE RECEPTOR BETA LIGAND BINDING DOMAIN IN COMPLEX WITH KB131084'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Farnegardh, M.]]
[[Category: Farnegardh, M.]]
[[Category: alternative splicing]]
[[Category: Alternative splicing]]
[[Category: deafness]]
[[Category: Deafness]]
[[Category: disease mutation]]
[[Category: Disease mutation]]
[[Category: dna-binding]]
[[Category: Dna-binding]]
[[Category: ligand binding domain]]
[[Category: Ligand binding domain]]
[[Category: metal-binding]]
[[Category: Metal-binding]]
[[Category: nuclear protein]]
[[Category: Nuclear protein]]
[[Category: nuclear receptor]]
[[Category: Nuclear receptor]]
[[Category: polymorphism]]
[[Category: Polymorphism]]
[[Category: receptor]]
[[Category: Receptor]]
[[Category: transcription]]
[[Category: Transcription]]
[[Category: transcription regulation]]
[[Category: Transcription regulation]]
[[Category: zinc]]
[[Category: Zinc]]
[[Category: zinc-finger]]
[[Category: Zinc-finger]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 08:18:39 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:52:44 2008''

Revision as of 05:18, 4 May 2008

File:2j4a.jpg

Template:STRUCTURE 2j4a

HUMAN THYROID HORMONE RECEPTOR BETA LIGAND BINDING DOMAIN IN COMPLEX WITH KB131084


Overview

A new high-affinity thyroid hormone antagonist 6 with druglike properties was designed and synthesized. The compound behaved as an antagonist in a cell transactivation assay, and in a first in vivo experiment in rats.

About this Structure

2J4A is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor., Koehler K, Gordon S, Brandt P, Carlsson B, Backsbro-Saeidi A, Apelqvist T, Agback P, Grover GJ, Nelson W, Grynfarb M, Farnegardh M, Rehnmark S, Malm J, J Med Chem. 2006 Nov 16;49(23):6635-7. PMID:17154490 Page seeded by OCA on Sun May 4 08:18:39 2008

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