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==Crystal structure of Rhodococcus jostii RHA1 IpdAB E105A COCHEA-COA complex==
==Crystal structure of Rhodococcus jostii RHA1 IpdAB E105A COCHEA-COA complex==
<StructureSection load='6coj' size='340' side='right' caption='[[6coj]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
<StructureSection load='6coj' size='340' side='right'caption='[[6coj]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6coj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhojr Rhojr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6COJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6COJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[6coj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_jostii_RHA1 Rhodococcus jostii RHA1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6COJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6COJ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F8G:S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl}+(5R,10R)-7-hydroxy-10-methyl-2-oxo-1-oxaspiro[4.5]dec-6-ene-6-carbothioate+(non-preferred+name)'>F8G</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RHA1_ro04651 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=101510 RHOJR]), RHA1_ro04650 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=101510 RHOJR])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F8G:S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl}+(5R,10R)-7-hydroxy-10-methyl-2-oxo-1-oxaspiro[4.5]dec-6-ene-6-carbothioate+(non-preferred+name)'>F8G</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6coj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6coj OCA], [http://pdbe.org/6coj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6coj RCSB], [http://www.ebi.ac.uk/pdbsum/6coj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6coj ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6coj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6coj OCA], [https://pdbe.org/6coj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6coj RCSB], [https://www.ebi.ac.uk/pdbsum/6coj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6coj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IPDA_RHOJR IPDA_RHOJR] Involved in the final steps of cholesterol and steroid degradation (PubMed:28377529, PubMed:29581275). Opens the last steroid ring of cholesterol by catalyzing the hydrolysis of (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA (COCHEA-CoA) to 6-methyl-3,7-dioxodecanedioyl-CoA (MeDODA-CoA) (Probable) (PubMed:29581275).<ref>PMID:28377529</ref> <ref>PMID:29581275</ref> <ref>PMID:28377529</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Rhojr]]
[[Category: Large Structures]]
[[Category: Crowe, A M]]
[[Category: Rhodococcus jostii RHA1]]
[[Category: Eltis, L D]]
[[Category: Crowe AM]]
[[Category: Strynadka, N C.J]]
[[Category: Eltis LD]]
[[Category: Watanabe, N]]
[[Category: Strynadka NCJ]]
[[Category: Workman, S D]]
[[Category: Watanabe N]]
[[Category: Worrall, L J]]
[[Category: Workman SD]]
[[Category: Cholesterol]]
[[Category: Worrall LJ]]
[[Category: Hydrolase]]
[[Category: Ring cleaving]]
[[Category: Virulence factor]]
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