5zk7: Difference between revisions
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==Stapled-peptides tailored against initiation of translation== | |||
<StructureSection load='5zk7' size='340' side='right' caption='[[5zk7]], [[Resolution|resolution]] 2.12Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5zk7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZK7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZK7 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MGT:7N-METHYL-8-HYDROGUANOSINE-5-TRIPHOSPHATE'>MGT</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zk7 OCA], [http://pdbe.org/5zk7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zk7 RCSB], [http://www.ebi.ac.uk/pdbsum/5zk7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zk7 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN]] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Auvin, S]] | |||
[[Category: Bashir, T]] | |||
[[Category: Brown, C J]] | |||
[[Category: Ciesielski, F]] | [[Category: Ciesielski, F]] | ||
[[Category: Frosi, Y]] | [[Category: Frosi, Y]] | ||
[[Category: Lama, D]] | [[Category: Lama, D]] | ||
[[Category: Lane, D P]] | |||
[[Category: Liberator, A]] | [[Category: Liberator, A]] | ||
[[Category: | [[Category: Nakhle, J]] | ||
[[Category: Tsomia, N]] | |||
[[Category: Uhring, M]] | [[Category: Uhring, M]] | ||
[[Category: | [[Category: Verma, C S]] | ||
[[Category: | [[Category: Cap dependent translation]] | ||
[[Category: Rna binding protein]] | |||
Revision as of 06:35, 21 February 2019
Stapled-peptides tailored against initiation of translation
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