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==Crystal structure of PLEKHM1 LIR in complex with human LC3C_8-125==
==Crystal structure of PLEKHM1 LIR in complex with human LC3C_8-125==
<StructureSection load='5dpw' size='340' side='right' caption='[[5dpw]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
<StructureSection load='5dpw' size='340' side='right'caption='[[5dpw]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5dpw]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DPW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DPW FirstGlance]. <br>
<table><tr><td colspan='2'>[[5dpw]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DPW FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5dpr|5dpr]], [[5dps|5dps]], [[5dpt|5dpt]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.185&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAP1LC3C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), PLEKHM1, KIAA0356 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dpw OCA], [https://pdbe.org/5dpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dpw RCSB], [https://www.ebi.ac.uk/pdbsum/5dpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dpw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dpw OCA], [http://pdbe.org/5dpw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dpw RCSB], [http://www.ebi.ac.uk/pdbsum/5dpw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dpw ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/PKHM1_HUMAN PKHM1_HUMAN]] Intermediate osteopetrosis. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MLP3C_HUMAN MLP3C_HUMAN]] Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruites all ATG8 family members to infecting bacteria such as S.Typhimurium.<ref>PMID:23022382</ref> [[http://www.uniprot.org/uniprot/PKHM1_HUMAN PKHM1_HUMAN]] Proposed to act as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Seems to be involved in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (PubMed:25498145). Involved in vesicular transport in the osteoclast (By similarity). May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7 (PubMed:20943950). May have a role in sialyl-lex-mediated transduction of apoptotic signals (PubMed:12820725). In case of infection contributes to Salmonella typhimurium pathogenesis by supporting the integrity of the Salmonella-containing vacuole (SCV) probably in concert with the HOPS complex and Rab7 (PubMed:25500191).[UniProtKB:Q5PQS0]<ref>PMID:12820725</ref> <ref>PMID:20943950</ref> <ref>PMID:25498145</ref> <ref>PMID:25500191</ref> 
[https://www.uniprot.org/uniprot/MLP3C_HUMAN MLP3C_HUMAN] Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruites all ATG8 family members to infecting bacteria such as S.Typhimurium.<ref>PMID:23022382</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Microtubule-associated protein|Microtubule-associated protein]]
*[[Microtubule-associated protein 3D structures|Microtubule-associated protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Dobson, R C.J]]
[[Category: Large Structures]]
[[Category: Ravichandran, A C]]
[[Category: Dobson RCJ]]
[[Category: Suzuki, H]]
[[Category: Ravichandran AC]]
[[Category: Autophagy]]
[[Category: Suzuki H]]
[[Category: Protein binding]]

Revision as of 21:54, 28 June 2023

Crystal structure of PLEKHM1 LIR in complex with human LC3C_8-125

5dpw, resolution 2.19Å

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