2jmc: Difference between revisions

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[[Image:2jmc.gif|left|200px]]
[[Image:2jmc.gif|left|200px]]


{{Structure
<!--
|PDB= 2jmc |SIZE=350|CAPTION= <scene name='initialview01'>2jmc</scene>
The line below this paragraph, containing "STRUCTURE_2jmc", creates the "Structure Box" on the page.
|SITE=
You may change the PDB parameter (which sets the PDB file loaded into the applet)
|LIGAND=
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY=
or leave the SCENE parameter empty for the default display.
|GENE= SPTAN1, SPTA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus])
-->
|DOMAIN=
{{STRUCTURE_2jmc|  PDB=2jmc |  SCENE= }}  
|RELATEDENTRY=[[1tuc|1TUC]], [[2jma|2JMA]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jmc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jmc OCA], [http://www.ebi.ac.uk/pdbsum/2jmc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jmc RCSB]</span>
}}


'''Chimer between Spc-SH3 and P41'''
'''Chimer between Spc-SH3 and P41'''
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[[Category: Martinez, J C.]]
[[Category: Martinez, J C.]]
[[Category: Nuland, N A.J van.]]
[[Category: Nuland, N A.J van.]]
[[Category: chimer]]
[[Category: Chimer]]
[[Category: p41]]
[[Category: P41]]
[[Category: spc-sh3]]
[[Category: Spc-sh3]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:01:36 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:59:10 2008''

Revision as of 06:01, 4 May 2008

File:2jmc.gif

Template:STRUCTURE 2jmc

Chimer between Spc-SH3 and P41


Overview

Here we present the high-resolution NMR structure of a chimera (SPCp41) between alpha-spectrin SH3 domain and the decapeptide p41. The tertiary structure mimics perfectly the interactions typically found in SH3-peptide complexes and is remarkably similar to that of the complex between the separate Spc-SH3 domain and ligand p41. Relaxation data confirm the tight binding between the ligand and SH3 part of the chimera. This chimera will serve as a tool for a deeper understanding of the relationship between structure and thermodynamics of binding using a combination of NMR, stability and site-directed mutagenesis studies, which can lead to an effective strategy for ligand design.

About this Structure

2JMC is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

The high-resolution NMR structure of a single-chain chimeric protein mimicking a SH3-peptide complex., Candel AM, Conejero-Lara F, Martinez JC, van Nuland NA, Bruix M, FEBS Lett. 2007 Feb 20;581(4):687-92. Epub 2007 Jan 22. PMID:17275816 Page seeded by OCA on Sun May 4 09:01:36 2008

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