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==Crystal structures of human orexin 2 receptor bound to the selective antagonist EMPA determined by serial femtosecond crystallography at SACLA==
==Crystal structures of human orexin 2 receptor bound to the selective antagonist EMPA determined by serial femtosecond crystallography at SACLA==
<StructureSection load='5ws3' size='340' side='right' caption='[[5ws3]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='5ws3' size='340' side='right'caption='[[5ws3]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ws3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WS3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WS3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ws3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Pyrococcus_abyssi_GE5 Pyrococcus abyssi GE5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WS3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=7MA:N-ethyl-2-[(6-methoxypyridin-3-yl)-(2-methylphenyl)sulfonyl-amino]-N-(pyridin-3-ylmethyl)ethanamide'>7MA</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HCRTR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=7MA:N-ethyl-2-[(6-methoxypyridin-3-yl)-(2-methylphenyl)sulfonyl-amino]-N-(pyridin-3-ylmethyl)ethanamide'>7MA</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ws3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ws3 OCA], [http://pdbe.org/5ws3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ws3 RCSB], [http://www.ebi.ac.uk/pdbsum/5ws3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ws3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ws3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ws3 OCA], [https://pdbe.org/5ws3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ws3 RCSB], [https://www.ebi.ac.uk/pdbsum/5ws3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ws3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/OX2R_HUMAN OX2R_HUMAN]] Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.  
[https://www.uniprot.org/uniprot/Q9V2J8_PYRAB Q9V2J8_PYRAB] [https://www.uniprot.org/uniprot/OX2R_HUMAN OX2R_HUMAN] Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Fujiwara, T]]
[[Category: Large Structures]]
[[Category: Hatsui, T]]
[[Category: Pyrococcus abyssi GE5]]
[[Category: Hirokawa, T]]
[[Category: Fujiwara T]]
[[Category: Horita, S]]
[[Category: Hatsui T]]
[[Category: Im, D]]
[[Category: Hirokawa T]]
[[Category: Iwata, S]]
[[Category: Horita S]]
[[Category: Joti, Y]]
[[Category: Im D]]
[[Category: Kameshima, T]]
[[Category: Iwata S]]
[[Category: Kimura, K]]
[[Category: Joti Y]]
[[Category: Kobayashi, T]]
[[Category: Kameshima T]]
[[Category: Nakane, T]]
[[Category: Kimura K]]
[[Category: Nango, E]]
[[Category: Kobayashi T]]
[[Category: Rosenbaum, D M]]
[[Category: Nakane T]]
[[Category: Sasanuma, M]]
[[Category: Nango E]]
[[Category: Shimamoto, K]]
[[Category: Rosenbaum DM]]
[[Category: Shimamura, T]]
[[Category: Sasanuma M]]
[[Category: Suno, R]]
[[Category: Shimamoto K]]
[[Category: Tono, K]]
[[Category: Shimamura T]]
[[Category: Tsujimoto, H]]
[[Category: Suno R]]
[[Category: Wang, J]]
[[Category: Tono K]]
[[Category: Yabashi, M]]
[[Category: Tsujimoto H]]
[[Category: Yamamoto, M]]
[[Category: Wang J]]
[[Category: Yamanaka, Y]]
[[Category: Yabashi M]]
[[Category: Yamashita, K]]
[[Category: Yamamoto M]]
[[Category: Receptor]]
[[Category: Yamanaka Y]]
[[Category: Signaling protein]]
[[Category: Yamashita K]]
Retrieved from "https://proteopedia.org/5ws3"