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'''Unreleased structure'''


The entry 6gr8 is ON HOLD  until Paper Publication
==Human AURKC INCENP complex bound to BRD-7880==
 
<StructureSection load='6gr8' size='340' side='right'caption='[[6gr8]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
Authors: Abdul Azeez, K.R., Sorrell, F.J., von Delft, F., Bountra, C., Knapp, S., Edwards, A.M., Arrowsmith, C., Elkins, J.M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6gr8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GR8 FirstGlance]. <br>
Description: Human AURKC INCENP complex bound to BRD-7880
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F8Z:1-[(2~{R},3~{S})-2-[[1,3-benzodioxol-5-ylmethyl(methyl)amino]methyl]-3-methyl-6-oxidanylidene-5-[(2~{S})-1-oxidanylpropan-2-yl]-3,4-dihydro-2~{H}-1,5-benzoxazocin-8-yl]-3-(4-methoxyphenyl)urea'>F8Z</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
[[Category: Elkins, J.M]]
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AURKC, AIE2, AIK3, AIRK3, ARK3, STK13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), INCENP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gr8 OCA], [http://pdbe.org/6gr8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gr8 RCSB], [http://www.ebi.ac.uk/pdbsum/6gr8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gr8 ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/AURKC_HUMAN AURKC_HUMAN]] Male infertility due to large-headed multiflagellar polyploid spermatozoa. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[[http://www.uniprot.org/uniprot/AURKC_HUMAN AURKC_HUMAN]] Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.<ref>PMID:15316025</ref> <ref>PMID:15499654</ref> <ref>PMID:15670791</ref> <ref>PMID:15938719</ref> <ref>PMID:21493633</ref> <ref>PMID:21531210</ref> <ref>PMID:27332895</ref>  [[http://www.uniprot.org/uniprot/INCE_HUMAN INCE_HUMAN]] Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with AURKB or AURKC. Seems to bind directly to microtubules. Controls the kinetochore localization of BUB1.<ref>PMID:15316025</ref> <ref>PMID:12925766</ref> <ref>PMID:16760428</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Arrowsmith, C]]
[[Category: Azeez, K R.Abdul]]
[[Category: Bountra, C]]
[[Category: Delft, F von]]
[[Category: Edwards, A M]]
[[Category: Elkins, J M]]
[[Category: Knapp, S]]
[[Category: Knapp, S]]
[[Category: Edwards, A.M]]
[[Category: Sorrell, F J]]
[[Category: Abdul Azeez, K.R]]
[[Category: Kinase]]
[[Category: Von Delft, F]]
[[Category: Sgc]]
[[Category: Bountra, C]]
[[Category: Structural genomic]]
[[Category: Arrowsmith, C]]
[[Category: Transferase]]
[[Category: Sorrell, F.J]]
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