6du8: Difference between revisions

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'''Unreleased structure'''


The entry 6du8 is ON HOLD until Jun 20 2020
==Human Polycsytin 2-l1==
<StructureSection load='6du8' size='340' side='right' caption='[[6du8]], [[Resolution|resolution]] 3.11&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6du8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DU8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DU8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6du8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6du8 OCA], [http://pdbe.org/6du8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6du8 RCSB], [http://www.ebi.ac.uk/pdbsum/6du8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6du8 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PK2L1_HUMAN PK2L1_HUMAN]] Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.<ref>PMID:10517637</ref> <ref>PMID:19812697</ref> <ref>PMID:23212381</ref> <ref>PMID:24336289</ref>  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We report the near atomic resolution (3.3 A) of the human polycystic kidney disease 2-like 1 (polycystin 2-l1) ion channel. Encoded by PKD2L1, polycystin 2-l1 is a calcium and monovalent cation-permeant ion channel in primary cilia and plasma membranes. The related primary cilium-specific polycystin-2 protein, encoded by PKD2, shares a high degree of sequence similarity, yet has distinct permeability characteristics. Here we show that these differences are reflected in the architecture of polycystin 2-l1.


Authors: Hulse, R.E., Clapham, D.E., Li, Z., Huang, R.K., Zhang, J.
Cryo-EM structure of the polycystin 2-l1 ion channel.,Hulse RE, Li Z, Huang RK, Zhang J, Clapham DE Elife. 2018 Jul 13;7. pii: 36931. doi: 10.7554/eLife.36931. PMID:30004384<ref>PMID:30004384</ref>


Description: Human Polycsytin 2-l1
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 6du8" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Clapham, D E]]
[[Category: Huang, R K]]
[[Category: Hulse, R E]]
[[Category: Li, Z]]
[[Category: Li, Z]]
[[Category: Clapham, D.E]]
[[Category: Zhang, J]]
[[Category: Zhang, J]]
[[Category: Hulse, R.E]]
[[Category: Membrane protein]]
[[Category: Huang, R.K]]
[[Category: Pc2l1]]
[[Category: Pkd2l1]]
[[Category: Polycystic 2-l1]]
[[Category: Trpp2]]
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