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'''Solution structure of the hypothetical protein AF2241 from Archaeoglobus fulgidus''' | '''Solution structure of the hypothetical protein AF2241 from Archaeoglobus fulgidus''' | ||
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[[Category: Semesib, A.]] | [[Category: Semesib, A.]] | ||
[[Category: Yee, A.]] | [[Category: Yee, A.]] | ||
[[Category: | [[Category: Beta-barrel]] | ||
[[Category: | [[Category: Ocsp]] | ||
[[Category: | [[Category: Ontario centre for structural proteomic]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: | [[Category: Unknown function]] | ||
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Revision as of 06:41, 4 May 2008
Solution structure of the hypothetical protein AF2241 from Archaeoglobus fulgidus
Overview
AF2241 is a hypothetical protein from Archaeoglobus fulgidus and it belongs to the PFam domain of unknown function 369 (DUF369). NMR structural determination reveals that AF2241 adopts a cyclophilin-like fold, with a beta-barrel core composed of eight beta-strands, one alpha-helix, and one 3(10) helix located at each end of the barrel. The protein displays a high structural similarity to TM1367, another member of DUF369 whose structure has been determined recently by X-ray crystallography. Structural similarity search shows that AF2241 also has a high similarity to human cyclophilin A, however, sequence alignment and electrostatic potential analysis reveal that the residues in the PPIase catalytic site of human cyclophilin A are not conserved in AF2241 or TM1367. Instead, a putative active site of AF2241 maps to a negatively charged pocket composed of 9 conserved residues. Our results suggest that although AF2241 adopts the same fold as the human cyclophilin A, it may have distinct biological function.
About this Structure
2NNZ is a Single protein structure of sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA.
Reference
Hypothetical protein AF2241 from Archaeoglobus fulgidus adopts a cyclophilin-like fold., Ai X, Li L, Semesi A, Yee A, Arrowsmith CH, Li SS, Choy WY, J Biomol NMR. 2007 Aug;38(4):353-8. Epub 2007 Jul 4. PMID:17610131 Page seeded by OCA on Sun May 4 09:41:20 2008
