6co8: Difference between revisions

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<StructureSection load='6co8' size='340' side='right' caption='[[6co8]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
<StructureSection load='6co8' size='340' side='right' caption='[[6co8]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6co8]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Zika_virus Zika virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CO8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CO8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6co8]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Zika_virus_zikv/h._sapiens/frenchpolynesia/10087pf/2013 Zika virus zikv/h. sapiens/frenchpolynesia/10087pf/2013]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CO8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CO8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6co8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6co8 OCA], [http://pdbe.org/6co8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6co8 RCSB], [http://www.ebi.ac.uk/pdbsum/6co8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6co8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6co8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6co8 OCA], [http://pdbe.org/6co8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6co8 RCSB], [http://www.ebi.ac.uk/pdbsum/6co8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6co8 ProSAT]</span></td></tr>
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<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
The recent rapid spread of Zika virus and its unexpected linkage to birth defects and an autoimmune neurological syndrome have generated worldwide concern. Zika virus is a flavivirus like the dengue, yellow fever, and West Nile viruses. We present the 3.8 angstrom resolution structure of mature Zika virus, determined by cryo-electron microscopy (cryo-EM). The structure of Zika virus is similar to other known flavivirus structures, except for the ~10 amino acids that surround the Asn(154) glycosylation site in each of the 180 envelope glycoproteins that make up the icosahedral shell. The carbohydrate moiety associated with this residue, which is recognizable in the cryo-EM electron density, may function as an attachment site of the virus to host cells. This region varies not only among Zika virus strains but also in other flaviviruses, which suggests that differences in this region may influence virus transmission and disease.
Among the several arthropod-borne human flaviviral diseases, the recent outbreak of Zika virus (ZIKV) has caused devastating birth defects and neurological disorders, challenging the world with another major public health concern. We report here the refined structure of the mature ZIKV at a resolution of 3.1 A as determined by cryo-electron microscopic single-particle reconstruction. The improvement in the resolution, compared with previous enveloped virus structures, was the result of optimized virus preparation methods and data processing techniques. The glycoprotein interactions and surface properties of ZIKV were compared with other mosquito-borne flavivirus structures. The largest structural differences and sequence variations occur at the glycosylation loop associated with receptor binding. Probable drug binding pockets were identified on the viral surface. These results also provide a structural basis for the design of vaccines against ZIKV.


The 3.8 A resolution cryo-EM structure of Zika virus.,Sirohi D, Chen Z, Sun L, Klose T, Pierson TC, Rossmann MG, Kuhn RJ Science. 2016 Apr 22;352(6284):467-70. doi: 10.1126/science.aaf5316. Epub 2016, Mar 31. PMID:27033547<ref>PMID:27033547</ref>
Refinement and Analysis of the Mature Zika Virus Cryo-EM Structure at 3.1 A Resolution.,Sevvana M, Long F, Miller AS, Klose T, Buda G, Sun L, Kuhn RJ, Rossmann MG Structure. 2018 May 29. pii: S0969-2126(18)30170-9. doi:, 10.1016/j.str.2018.05.006. PMID:29958768<ref>PMID:29958768</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Zika virus]]
[[Category: Zika virus zikv/h. sapiens/frenchpolynesia/10087pf/2013]]
[[Category: Buda, G]]
[[Category: Buda, G]]
[[Category: Klose, T]]
[[Category: Klose, T]]
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