2i1n: Difference between revisions

<StructureSection load='2i1n' size='340' side='right' caption='[[2i1n]], [[Resolution|resolution]] 1.85&Aring;' scene=''>

<table><tr><td colspan='2'>[[2i1n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I1N FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DLG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1n OCA], [http://pdbe.org/2i1n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i1n RCSB], [http://www.ebi.ac.uk/pdbsum/2i1n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2i1n ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/DLG3_HUMAN DLG3_HUMAN]] Defects in DLG3 are the cause of mental retardation X-linked type 90 (MRX90) [MIM:[http://omim.org/entry/300850 300850]]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.<ref>PMID:15185169</ref>   

[[http://www.uniprot.org/uniprot/DLG3_HUMAN DLG3_HUMAN]] Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.