2hw5: Difference between revisions
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==The crystal structure of human enoyl-coenzyme A (CoA) hydratase short chain 1, ECHS1== | ==The crystal structure of human enoyl-coenzyme A (CoA) hydratase short chain 1, ECHS1== | ||
<StructureSection load='2hw5' size='340' side='right' caption='[[2hw5]], [[Resolution|resolution]] 2.55Å' scene=''> | <StructureSection load='2hw5' size='340' side='right'caption='[[2hw5]], [[Resolution|resolution]] 2.55Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2hw5]] is a 6 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2hw5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HW5 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COO:CROTONYL+COENZYME+A'>COO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COO:CROTONYL+COENZYME+A'>COO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ECHS1 ([ | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ECHS1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Enoyl-CoA_hydratase Enoyl-CoA hydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.17 4.2.1.17] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hw5 OCA], [https://pdbe.org/2hw5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hw5 RCSB], [https://www.ebi.ac.uk/pdbsum/2hw5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hw5 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/ECHM_HUMAN ECHM_HUMAN]] Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 23: | Line 23: | ||
==See Also== | ==See Also== | ||
*[[Enoyl-CoA hydratase|Enoyl-CoA hydratase]] | *[[Enoyl-CoA hydratase 3D structures|Enoyl-CoA hydratase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Enoyl-CoA hydratase]] | [[Category: Enoyl-CoA hydratase]] | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith, C]] | [[Category: Arrowsmith, C]] | ||
[[Category: Debreczeni, J]] | [[Category: Debreczeni, J]] | ||
Revision as of 07:22, 24 March 2021
The crystal structure of human enoyl-coenzyme A (CoA) hydratase short chain 1, ECHS1
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Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Enoyl-CoA hydratase
- Human
- Large Structures
- Arrowsmith, C
- Debreczeni, J
- Delft, F von
- Edwards, A
- Gileadi, O
- Gorrec, F
- Kavanagh, K
- Niesen, F
- Oppermann, U
- Pike, A C.W
- Structural genomic
- Salah, E
- Sundstrom, M
- Turnbull, A P
- Ugochukwu, E
- Umeano, C
- Weigelt, J
- Beta-oxidation
- Coa
- Enoyl-coa hydratase
- Fatty acid metabolism
- Hydratase/isomerase superfamily
- Lyase
- Sgc
