6dxt: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "6dxt" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
==Structure of USP5 zinc-finger ubiquitin binding domain co-crystallized with 3-(5-phenyl-1,3,4-oxadiazol-2-yl)propanoate== | |||
<StructureSection load='6dxt' size='340' side='right' caption='[[6dxt]], [[Resolution|resolution]] 1.95Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6dxt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DXT FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HHY:3-(5-phenyl-1,3,4-oxadiazol-2-yl)propanoic+acid'>HHY</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dxt OCA], [http://pdbe.org/6dxt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dxt RCSB], [http://www.ebi.ac.uk/pdbsum/6dxt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dxt ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/UBP5_HUMAN UBP5_HUMAN]] Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.<ref>PMID:19098288</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Ubiquitinyl hydrolase 1]] | |||
[[Category: Arrowsmith, C M]] | |||
[[Category: Bountra, C]] | |||
[[Category: Edwards, A M]] | |||
[[Category: Franzoni, I]] | [[Category: Franzoni, I]] | ||
[[Category: Freitas, R Ferreira de]] | |||
[[Category: Harding, R J]] | |||
[[Category: Mann, M K]] | |||
[[Category: Ravichandran, M]] | [[Category: Ravichandran, M]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Schapira, M]] | [[Category: Schapira, M]] | ||
[[Category: | [[Category: Deubiquitinase]] | ||
[[Category: | [[Category: Hydrolase]] | ||
[[Category: | [[Category: Sgc]] | ||
[[Category: | [[Category: Ubiquitin]] | ||
[[Category: Usp5]] | |||
[[Category: | |||
Revision as of 21:49, 9 August 2018
Structure of USP5 zinc-finger ubiquitin binding domain co-crystallized with 3-(5-phenyl-1,3,4-oxadiazol-2-yl)propanoate
| ||||||||||||
