6gz6: Difference between revisions
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==Structure of a left-handed G-quadruplex== | |||
<StructureSection load='6gz6' size='340' side='right'caption='[[6gz6]], [[Resolution|resolution]] 2.01Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6gz6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GZ6 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gz6 OCA], [http://pdbe.org/6gz6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gz6 RCSB], [http://www.ebi.ac.uk/pdbsum/6gz6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gz6 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Recently, we observed the first example of a left-handed G-quadruplex structure formed by natural DNA, named Z-G4. We analysed the Z-G4 structure and inspected its primary 28-nt sequence in order to identify motifs that convey the unique left-handed twist. Using CD, NMR spectroscopy and X-ray crystallography, we revealed a minimal sequence motif of 12 nt GTGGTGGTGGTG for the left-handed DNA G-quadruplex formation, which is found to be highly abundant in the human genome. A systematic analysis of thymine loop mutations revealed a moderate sequence tolerance, which would further broaden the space of sequences prone to left-handed G-quadruplex formation. | |||
A minimal sequence for left-handed G-quadruplex formation.,Phan AT Angew Chem Int Ed Engl. 2018 Nov 27. doi: 10.1002/anie.201812628. PMID:30481397<ref>PMID:30481397</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6gz6" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Bakalar, B]] | |||
[[Category: Heddi, B]] | |||
[[Category: Mechulam, Y]] | |||
[[Category: Phan, A T]] | |||
[[Category: Schmitt, E]] | |||
[[Category: Dna]] | |||
[[Category: G-quadruplex]] | |||
Latest revision as of 06:47, 24 April 2019
Structure of a left-handed G-quadruplex
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